ArticleAnnals of medicine2025
The impact of hypertension on hearing loss phenotypes and its causal mediation underlying abnormal BMI: findings from the China national health survey 2023.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trends and mechanistic insights into hypertension-associated hearing loss: a 20-year perspective (2005-2025).Frontiers in molecular neuroscience · 2026Pooled it
- Association between hypertension status and severity and tinnitus: a cross-sectional analysis of the Fasa adult cohort study.BMJ open · 2026Article
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22 authors.
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Abstract
backgroundThe relationships of hypertension and its temporal (duration), phenotypic (stage), and hemodynamic (pulse pressure) parameter with hearing loss (HL) remain unclear. We aimed to (1) characterize hypertension parameter-specific effects on HL, and (2) quantify contribution of hypertension in mediating the association between abnormal BMI and HL, given that abnormal BMI has been associated with an increased risk of HL.
methodsWe conducted a cross-sectional analysis using data from the 2023 China National Health Survey, including 5918 participants aged 20-88 years. Hypertension was defined as self-reported physician diagnosis, antihypertensive medication use, or averaged systolic/diastolic blood pressure ≥140/90 mmHg. Hearing outcomes were classified by frequency (low/mid, speech, and high) and severity (mild and moderate to complete). Binary and ordinal logistic regression model was employed to calculated ORs and 95% CI of hypertension parameters for frequency-specific general HL (binary) and ordinal severity of HL, respectively.
resultsA total of 2432 (41.1%) had hypertension and 2690-3915 (45.45%-66.16%) had HL. Those with hypertension, prolonged duration, high stage, and abnormal pulse pressure have higher hearing thresholds. In fully adjusted models, hypertension was independently associated with HL, particularly for high frequency, the ORs (95% CIs) were 1.69 (1.46, 1.95) and 1.57 (1.40, 1.76) for binary general and ordinal severity high-frequency HL, respectively. The associations between abnormal BMI and HL were mediated by hypertension significantly, the mediation proportions were 18%-51% for general HL and 21%-48% for severity.
conclusionHypertension was not only an independent risk factor for HL but a mediator in the relationship between abnormal BMI and HL, particularly at high frequency and the risk and severity of HL worsens with hypertension duration and stage.
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