Evidence map›Paper›PMID 41169087›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Flow-Enabled, Modular Access to α,α-Difluoromethylene Amines.

Dmitrii Nagornîi, Pietro Ronco, Khadijah Anwar, Nikolaos Kaplaneris, James J Douglas, Timothy Noël

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Flow-Enabled, Modular Access to α,α-Difluoromethylene Amines.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dmitrii NagornîiFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904 XH, Amsterdam, 1098, The Netherlands.
Pietro RoncoFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904 XH, Amsterdam, 1098, The Netherlands.
Khadijah AnwarFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904 XH, Amsterdam, 1098, The Netherlands.
Nikolaos KaplanerisFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904 XH, Amsterdam, 1098, The Netherlands.
James J DouglasEarly Chemical Development, Pharmaceutical Sciences R&D, AstraZeneca, Charter Way, Macclesfield, SK10 2NA, UK.
Timothy NoëlFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904 XH, Amsterdam, 1098, The Netherlands.ORCID https://orcid.org/0000-0002-3107-6927

Funding

ERC 101044355European Union 101057430
6 · The paper itself

Abstract

The α,α-difluoromethylene amine (NCF

Indexed as

DifluorinationFlow chemistryIsosteresLate‐stage functionalizationLibrary synthesis

Identifiers

PMID41169087
PMCPMC12723450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.