Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.

Nol Duindam, Jasper E Bos, Felix van Nifterik, Sander J Wezenberg

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Light-Enhanced Chloride Transport by Thiourea-Appended Molecular Motor.Angewandte Chemie (International ed. in English) · 2026
Article
Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.Angewandte Chemie (International ed. in English) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nol DuindamLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Jasper E BosLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Felix van NifterikLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Sander J WezenbergLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.ORCID 0000-0001-9192-3393

Funding

European Research Council 802830Leiden Institute of Chemistry (LIC)National Roadmap Large-Scale NMR Facility 184.035.002SURF Cooperative EINF-7179

6 · The paper itself

Abstract

Synthetic anion transporters have emerged as promising therapeutic agents. However, their targeting ability is still low. Herein, we present hemi-indigiosin, which is structurally related to prodigiosin-a well-studied natural product exhibiting a wide range of biological activities. Our hemi-indigiosin is shown to have similar HCl transport selectivity and pH-dependent activity as prodigiosin, while in addition it can be deactivated by irradiation with visible light. This deactivation is effective due to high photoconversion from the active chloride-binding Z-isomer to the inactive E-isomer, not exposing a chloride-binding site. Transport activity is thus controlled by both pH change and light, which will allow improved targeting of pathological sites and prevent ecological impact after drug excretion into the environment.

Indexed as

IndolesLightChloridesHumansHydrogen-Ion ConcentrationMolecular StructureProdigiosinChloridesIndolesProdigiosinAnion transportHemi‐indigoLipid bilayersMolecular switchesPhotochromism

Identifiers

PMID41169028

DOI10.1002/anie.202515930

PMCPMC12707358

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.