Evidence map›Paper›PMID 41168886›Full record

ArticleJournal of cardiovascular imaging2025

Predicting outcomes in patients with pulmonary hypertension using right ventricular global longitudinal strain versus tricuspid annular plane systolic excursion (TAPSE) and fractional area change: a retrospective analysis.

Noura Alturaif, Emily Lin, Anirudh Sundararaghavan, Valentina Mercurio, Tucker Wilkinson, Thomas Hilton, Onyedika Ilonze, Khadijah Breathett, Jane Kabwe, Joseph Phiri and 7 more

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In one paragraph

Article in Journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Noura AlturaifLung Health Department, Organ Transplant Centre, Faisal Specialist Hospital and Research Centre, Riyadh, King, Saudi Arabia. Naalturaif@hotmail.com.
Emily LinUniversity of Virginia School of Medicine, Charlottesville, VA, USA.
Anirudh SundararaghavanDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Valentina MercurioDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Tucker WilkinsonDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Thomas HiltonDepartment of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Onyedika IlonzeCardiovascular Department, Indiana University School of Medicine, Indiana, IN, USA.
Khadijah BreathettCardiovascular Department, Indiana University School of Medicine, Indiana, IN, USA.
Jane KabweDepartment of Anesthesia and Critical Care, National Heart Hospital, Lusaka, Zambia.
Joseph PhiriDepartment of Adult Cardiology, National Heart Hospital, Lusaka, Zambia.
Brian GrahamPulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA.
Joan F HiltonDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Andrew MihalekDepartment of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, USA.
Nicholas AshurCardiovascular Department, University of Virginia, Charlottesville, VA, USA.
Daniel PattersonCardiovascular Department, University of Virginia, Charlottesville, VA, USA.
Kenneth BilchickCardiovascular Department, University of Virginia, Charlottesville, VA, USA.
Sula MazimbaCardiovascular Department, University of Virginia, Charlottesville, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary hypertension (PH) is a progressive clinical condition that eventually leads to right ventricular (RV) failure. RV function is the primary determinant of morbidity and mortality in patients with PH. RV global longitudinal strain (RVGLS) is a promising echocardiographic metric used to assess RV function in this setting. Our study aimed to compare the ability of RVGLS, tricuspid annular plane systolic excursion (TAPSE) and fractional area change (FAC) to predict adverse outcomes in patients with PH.

methodsWe retrospectively evaluated 315 patients with PH of diverse etiologies with 62% constitute of WHO group 2 disease, who were followed at the PH clinic at the University of Virginia, from March 2012 to December 2018. We included all adult patients who met the hemodynamic definition of PH with right heart catheterization and who underwent echocardiography within 1 month of each other.

resultsApproximately half of the cohort was female, with a mean age of 64 ± 14 years. We found a strong correlation between RVGLS and FAC (r =  - 0.55, P < 0.001). Furthermore, there was a significant correlation between RVGLS and invasive hemodynamics. Compared with the TAPSE, the RVGLS stratified by quartiles was associated with mortality at 5 years and hospitalization.

conclusionRVGLS is an echocardiographic marker that correlates closely with FAC and invasive pulmonary hemodynamics. In this study, both RVGLS and FAC were associated with 5-year mortality, whereas TAPSE was not. Notably, only RVGLS showed a significant association with hospitalization, suggesting that it may provide additional prognostic value in patients with PH.

Indexed as

EchocardiographyOutcomePulmonary hypertensionRight ventricular functionStrain

Identifiers

PMID41168886
PMCPMC12573895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.