Evidence map›Paper›PMID 41168856›Full record

ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2025

The Chinese herb component salvianolic acid B induces copper-mediated reactive oxygen species generation and oxidative DNA damage.

Hatasu Kobayashi, Kiyoshi Fukuhara, Akiko Ohno, Yuichiro Hirao, Hiroshi Katoh, Yurie Mori, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Salvianolic Acids and Their Pharmacological Promise in Kidney Diseases: A Narrative Review.International journal of nephrology and renovascular disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hatasu KobayashiDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Kiyoshi FukuharaDivision of Organic and Medicinal Chemistry, School of Pharmacy, Showa Medical University, Tokyo, 142-8555, Japan.
Akiko OhnoDivision of Genome Safety Science, Center for Biological Safety & Research, National Institute of Health Sciences, Kawasaki, Kanagawa, 210-9501, Japan.
Yuichiro HiraoDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Hiroshi KatohDivision of Plant Functional Genomics, Advanced Science Research Promotion Center, Organization for Research Initiative and Promotion, Mie University, Tsu, Mie, 514-8507, Japan.
Yurie MoriDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Shosuke KawanishiFaculty of Pharmaceutical Science, Suzuka University of Medical Science, Suzuka, Mie, 513-8670, Japan.
Mariko MurataDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Shinji OikawaDepartment of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan. s-oikawa@med.mie-u.ac.jp.

Funding

Japan Society for the Promotion of Science 19H03885
6 · The paper itself

Abstract

backgroundSalvianolic acid B (Sal B), a natural polyphenol with potential therapeutic applications, has been reported to induce reactive oxygen species (ROS) generation. However, its underlying mechanism has not yet been fully elucidated. In this study, we investigated copper-mediated oxidative DNA damage induced by Sal B.

resultsSal B significantly increased the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in HL-60 cells, but not in H

conclusionsThe potential pro-oxidant risk of Sal B should be carefully evaluated when used as a therapeutic agent.

Indexed as

8-oxo-7,8-dihydro-2′-deoxyguanosineCopperDanshenDNA damageNADHPolyphenolReactive oxygen speciesSalvianolic acid B

Identifiers

PMID41168856
PMCPMC12574035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.