Evidence map›Paper›PMID 41168843›Full record

ArticleOne health outlook2025

Serologic evidence of orthomarburgviruses and an orthoebolavirus in frugivorous Malagasy bats.

Marana S Rekedal, Emily Cornelius Ruhs, Hafaliana Christian Ranaivoson, Neil Mittal, Spencer L Sterling, Gwenddolen Kettenburg, Angelo Andrianiaina, Santino Andry, Lianying Yan, Axel T Lehrer and 5 more

Abstract read
In one paragraph

Article in One health outlook, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marana S RekedalUniformed Services University of Health Sciences, Bethesda, MD, USA.
Emily Cornelius RuhsUniversity of Chicago, Chicago, IL, USA.
Hafaliana Christian RanaivosonUniversity of Chicago, Chicago, IL, USA.
Neil MittalUniformed Services University of Health Sciences, Bethesda, MD, USA.
Spencer L SterlingUniformed Services University of Health Sciences, Bethesda, MD, USA.
Gwenddolen KettenburgUniversity of Chicago, Chicago, IL, USA.
Angelo AndrianiainaThe University of Antananarivo, Antananarivo, Madagascar.
Santino AndryThe University of Antananarivo, Antananarivo, Madagascar.
Lianying YanUniformed Services University of Health Sciences, Bethesda, MD, USA.
Axel T LehrerUniversity of Hawai'i at Mānoa, Honolulu, HI, USA.
Jean-Michel HéraudInstitut Pasteur de Madagascar, Antananarivo, Madagascar.
Vincent LacosteInstitut Pasteur de Madagascar, Antananarivo, Madagascar.
Philippe DussartInstitut Pasteur de Madagascar, Antananarivo, Madagascar.
Cara E Brook *University of Chicago, Chicago, IL, USA.
Eric D Laing *Uniformed Services University of Health Sciences, Bethesda, MD, USA. Eric.laing@usuhs.edu.

Funding

Crossing scales to predict and prevent bat virus zoonoses in a Madagascar ecosystemDP2AI171120 · NIAID · UNIVERSITY OF CHICAGO · PI Cara Brook · 2022 to 2026
$2.5M
Investigating seasonal drivers of viral zoonoses from Madagascar fruit batsR01AI129822 · NIAID · PASTEUR INSTITUTE FROM MADAGASCAR · PI DUSSART, PHILIPPE · 2017 to 2021
$674k
Defense Advanced Research Projects Agency D18AC00031National Institute of Allergy and Infectious Diseases 1R01AI129822NIAID NIH HHS DP2 AI171120NIAID NIH HHS R01 AI129822Uniformed Services University of the Health Sciences MIC-73-12915
6 · The paper itself

Abstract

Recent outbreaks of Marburg virus disease in regions of sub-Saharan Africa without prior record such as Ghana, Tanzania, Equatorial Guinea, and Rwanda challenge the current understanding of areas at-risk for filovirus spillover. The orthomarburgvirus host Rousettus aegyptiacus exists in these regions, and has a sister species, Rousettus madagascariensis, native only to the island of Madagascar. We expand on previous surveillance of frugivorous bats in Madagascar, and detect seroreactivity against an orthoebolavirus antigenically-related to Bundibugyo virus at 1.50-5.06% seroprevalence in Rousettus madagascariensis. Notably, we identify R. madagascariensis as an orthomarburgvirus-host species of interest in Madagascar, the first record of this virus genus on the island. We document seroprevalences of 15.36-29.78% for Ravn virus and 12.55-33.33% for Marburg virus in R. madagascariensis. These findings will guide future biosurveillance efforts to assess filovirus spillover risk in Madagascar.

Indexed as

BatsFilovirusesMadagascarMarburg virusSurveillance

Identifiers

PMID41168843
PMCPMC12577238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.