Evidence map›Paper›PMID 41168829›Full record

ArticleJournal of experimental & clinical cancer research : CR2025

SLAMF7 promotes TCRαβ

Nan Xu, Peiyang Fang, Longyang Zhou, Xiaotong Han, Yuan Jiang, Xiyu Wang, Jingjing Zhu, Buer Li, Zihan Zhang, Hua Jin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nan XuMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Peiyang FangMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Longyang ZhouMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Xiaotong HanMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Yuan JiangMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Xiyu WangMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Jingjing ZhuMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Buer LiLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Zihan ZhangMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Hua JinMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Xiaonan DuMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Guangyong SunMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. sungy@ccmu.edu.cn.
Dong ZhangMedical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. zhangd@ccmu.edu.cn.

Funding

Beijing Municipal Administration of Hospitals' Ascent Plan DFL20220103Chinese Institutes for Medical Research, Beijing CX24PY16National Natural Science Foundation of China 82270606National Natural Science Foundation of China 82370578Natural Science Foundation of Beijing Municipality 7232034Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202510Reform and Development Program of Beijing Institute of Respiratory Medicine (Ggyfz202505 Ggyfz202505Youth Beijing Scholar 035
6 · The paper itself

Abstract

backgroundTCRαβ

methodsSignaling lymphocytic activation molecule factor 7 (SLAMF7) expression in murine and human DNT were evaluated. The antitumor activities were compared between SLAMF7

resultsThe expression of SLAMF7 was markedly increased on DNT upon activation. SLAMF7

conclusionsSLAMF7 is a key regulator of DNT-mediated cytotoxicity and a promising target for improving DNT cell function in cancer therapy.

Indexed as

GlutamineSignaling Lymphocytic Activation Molecule FamilyT-LymphocytesAnimalsCell Line, TumorHumansMiceGlutamineSignaling Lymphocytic Activation Molecule FamilySLAMF7 protein, humanCancer immunotherapyDouble negative T cellsERKGlutamine metabolismSLAMF7

Identifiers

PMID41168829
PMCPMC12574265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.