ArticleBMC psychiatry2025
Schizophrenia and sensory modulation problems: the relationship between severity, depression and sensory responsiveness.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
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3 authors.
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Abstract
backgroundSensory modulation difficulties have been increasingly recognized in schizophrenia, with neurophysiological evidence indicating altered sensory processing. However, how these abnormalities relate to symptomatology and depressive features in daily life remains underexplored. This study aimed to investigate the associations between sensory responsiveness, symptom severity and depressive symptoms in individuals with schizophrenia.
methodsA cross-sectional study was conducted with 74 outpatients diagnosed with schizophrenia. Participants completed the Sensory Responsiveness Questionnaire (SRQ), and clinicians rated symptom severity using the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia (CDSS). The relationship between schizophrenia symptoms, sensory integration and depressive symptoms was evaluated by correlation analysis.
resultsThe mean age was 41.4 ± 12.5 years, with a mean duration of illness was 13.8 ± 11.1 years. The pleasure subscale of the SRQ was positively correlated with PANSS positive symptoms (r = 0.299, p < 0.001) and general psychopathology (r = 0.342, p < 0.001). Severity of depression was significantly associated with all PANSS subscales.
conclusionThese findings indicate altered sensory responses in individuals with schizophrenia, particularly in relation to positive symptoms and general psychopathology. This supports the clinical relevance of incorporating sensory profiling into assessment and therapeutic planning in schizophrenia care.
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