ArticleBMC research notes2025
Parental clinical manifestation association with newborn immune senescence and telomere biology in Pakistan.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study investigates the association of parental clinical manifestations with newborn telomere biology and immune senescence markers, utilising 204 parent-newborn triads in Karachi, Pakistan. The demographic data collection was followed by quantification of telomere length (TL) using quantitative PCR, while Sanger sequencing was performed to analyse variants in telomerase genes [Telomere Reverse Component (TERC) and Telomerase Reverse Transcriptase (TERT)]. Moreover, flow cytometry was used to analyse immune senescence markers CD57 and Killer cell lectin-like receptor G1 (KLRG1).
resultsThe study revealed that immune senescence markers (CD57⁺KLRG1⁺) (3.5 ± 5.49, 3.1 ± 1.27) were significantly overexpressed in newborns from the diseased parent (diabetes, hypertension) (p = 0.04), and particularly KLRG1
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