ArticleChemistry, an Asian journal2026
Linkage-Editing of 6,6'-Diacyl Neotrehalose and Evaluation of Mincle Activation Ability.
Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Synthetic Ligands of Myeloid C-Type Lectin Receptors.Chembiochem : a European journal of chemical biology · 2026Review
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8 authors.
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Abstract
Trehalose dimycolates (TDMs), prominent glycolipid components of the mycobacterial cell wall, consist of an α,α-trehalose scaffold acylated at the O6 and O6' positions with long-chain mycolic acids. TDMs and related 6,6'-diacyl trehaloses are recognized by macrophage-inducible C-type lectin (Mincle) and exhibit strong immune-stimulating effects. Accordingly, 6,6'-diacyl trehaloses have attracted attention as potential vaccine adjuvants. In contrast, 6,6'-diacyl neotrehalose, which features an α,β-trehalose scaffold, is a less potent ligand of Mincle. Herein, we applied a linkage-editing strategy to 6,6'-diacyl neotrehalose to synthesize three types of C-glycoside analogs: (R)-CHF-, (S)-CHF-, and CH
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