Towards Better Assisted Reproductive Techniques Outcomes: Using Platelet-Rich Plasma to Improve Sperm Motility.

Serhat Yentur, Yunus Emre Dusunus, Ibrahim Ogulcan Canitez, Gokhan Cil, Aykut Colakerol, Ismail Engin Kandirali

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Serhat YenturBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey.

Yunus Emre DusunusBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey. yunusdusunus@gmail.com.ORCID 0009-0007-3428-547X

Ibrahim Ogulcan CanitezBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey.

Gokhan CilBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey.

Aykut ColakerolBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey.

Ismail Engin KandiraliBagcilar Training and Research Hospital, Istanbul Bagcilar Egitim ve Arastirma Hastanesi, Urology Clinic, Istanbul, Merkez Neighbourhood Dr. Sadık AHMET Street, Bagcilar, 34200, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the effect of platelet-rich plasma (PRP) on sperm motility in men with asthenozoospermia and assess its potential use in intrauterine insemination (IUI). MATERIALS AND

methodsA prospective randomized controlled pilot study was conducted with 40 men diagnosed with asthenozoospermia. Semen samples were divided into two equal parts: one treated with autologous, non-activated PRP and the other serving as control. Sperm motility was assessed at 1, 3, 6, and 24 h using a Makler chamber. A two-step centrifugation method was used for PRP preparation, and all samples underwent identical swim-up protocols. Data were analyzed using two-way repeated measures ANOVA.

resultsPRP-treated samples showed significantly higher motility than controls at all time points (p < 0.001). PRP also slowed the decline in motility over time. At 24 h, motility was 50.5% in the PRP group versus 21.1% in controls. Statistical analysis confirmed normal data distribution.

conclusionPRP significantly enhances and preserves sperm motility during in vitro incubation. These findings suggest that PRP may serve as a supportive option in sperm preparation for IUI, potentially reducing the need for more invasive techniques. Further studies are warranted to evaluate clinical outcomes.

Indexed as

AsthenozoospermiaPlatelet-Rich PlasmaReproductive Techniques, AssistedSperm MotilityAdultFemaleHumansMalePilot ProjectsPregnancyProspective StudiesTreatment OutcomeIntrauterine insemination (IUI)In vitro fertilization (IVF)Platelet-rich plasma (PRP)Sperm motility

Identifiers

PMID41168640

DOI10.3390/cells8050466

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.