ArticleJournal of nephrology2025
The association between CKD and frailty in the FRASNET study: suggestion of a novel eGFR threshold as a key determinant of frailty in the elderly.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFrailty, a geriatric syndrome marked by reduced physiological reserves, has been linked to organ dysfunction. However, the specific contribution of kidney function to frailty remains underexplored. This study aims to assess the impact of kidney function on frailty in a large population of older adults.
methodsThe FRASNET cohort, including elderly, non hospitalized individuals, was evaluated for frailty, markers of kidney, glomerular, and tubular function, and for anthropometric parameters.
resultsWe included 1183 individuals in this study (59.9% females, age 65-93). Among them, 27.7% of subjects were classified as robust, 37.6% were pre-frail, and 34.7% were frail. The prevalence of frailty increased with age (43% in individuals over 76 years of age) and was associated with obesity (28.3%) and polytherapy (23.2%). Whole estimated glomerular filtration rate (eGFR) was 73.8 (IQR 62.4, 84.7) ml/min/1.73 m
conclusionThis study revealed a strong relationship between CKD and frailty, identifying a new eGFR threshold associated with frailty in older adults. The alterations in age- and frailty-dependent sodium handling highlight the potential role of the often-overlooked tubular function in older individuals.
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