SMURF2-Mediated Ubiquitination and Degradation of HOXA5 Augments Endoplasmic Reticulum Stress in Alveolar Epithelial Type II Cells Induced by LPS.

Lei Wang, Chengjie Jiang, Jinzhong Dong, Weijian Le

Abstract read

In one paragraph

Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei WangDepartment of Critical Care Medicine, the First Affiliated Hospital of Ningbo University, 59 Liuting Street, Haishu District, Ningbo, 315700, Zhejiang, People's Republic of China.

Chengjie JiangDepartment of Critical Care Medicine, the First Affiliated Hospital of Ningbo University, 59 Liuting Street, Haishu District, Ningbo, 315700, Zhejiang, People's Republic of China.

Jinzhong DongDepartment of Critical Care Medicine, the First Affiliated Hospital of Ningbo University, 59 Liuting Street, Haishu District, Ningbo, 315700, Zhejiang, People's Republic of China.

Weijian LeDepartment of Critical Care Medicine, the First Affiliated Hospital of Ningbo University, 59 Liuting Street, Haishu District, Ningbo, 315700, Zhejiang, People's Republic of China. fyylejianwei@nbu.edu.cn.ORCID http://orcid.org/0009-0005-7714-834X

Funding

Ningbo Clinical Research Center for Emergency and Critical Diseases 2024L003the Project of Ningbo Key R&D Plan and "Unveiling and Leading" 2023Z174Zhejiang medicine and health science and technology project 2025KY238

6 · The paper itself

Abstract

Acute lung injury (ALI) is a clinical syndrome characterized by pulmonary inflammatory and endoplasmic reticulum stress (ERS). Nevertheless, the involvement of Homeobox A5 (HOXA5) in ERS of alveolar epithelial type II (ATII) cells remains unclear. RT-qPCR and western blot were employed to detect the expression of HOXA5, SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2), Fatty-acid-binding protein 4 (FABP4), inflammatory factors, and ERS-related proteins. The MTT measured cell viability. Calcium Assay was employed to measure intraluminal Ca

Indexed as

Alveolar Epithelial CellsEndoplasmic Reticulum StressHomeodomain ProteinsUbiquitin-Protein LigasesAnimalsApoptosisCell LineHumansLipopolysaccharidesProteolysisRatsUbiquitinationHomeodomain ProteinsLipopolysaccharidesSmurf2 protein, ratUbiquitin-Protein LigasesAcute lung injuryEndoplasmic reticulum stressFABP4HOXA5LPSSMURF2

Identifiers

PMID41168616

DOI10.2298/VSP240422050J

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.