Evidence map›Paper›PMID 41168547›Full record

ReviewBiogerontology2025

The aging male: impact of aging on male reproduction.

R E Akhigbe, P A Oyedokun, A E Adeogun, O O Ogunleye, C A Adegbola, T M Akhigbe

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R E AkhigbeDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. reakhigbe@gmail.com.
P A OyedokunDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
A E AdeogunReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
O O OgunleyeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
C A AdegbolaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
T M AkhigbeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a complex process that includes chronological aging and cellular aging. Although chronological aging is irreversible, cellular aging, which is reversible, is closely associated with chronological aging. Understanding the complexity of the impact and mechanisms of aging on the male reproductive function is crucial in maintaining male fertility. This study reviews the effects and mechanisms associated with aging in males on male reproductive health. It also provides potential therapeutic strategies for alleviating the reproductive consequences of aging in males. Evidence from the literature revealed that aging suppresses testicular steroidogenesis and circulating testosterone, lowers spermatogenesis and sperm quality, and induces erectile dysfunction. These adverse events are mediated by mitochondrial dysfunction and reduced ATP production, oxidative stress, inflammation, apoptosis, and DNA damage. More so, telomere shortening, cellular senescence, and epigenetic modification play crucial roles. Modulation of these processes with antioxidants such as vitamin C, vitamin E, CoQ10, and zinc attenuates cellular aging and promotes male reproductive health.

Indexed as

AgingReproductionAnimalsAntioxidantsCellular SenescenceHumansInfertility, MaleMaleOxidative StressSpermatogenesisTestisAntioxidantsAgingAntioxidantsMitochondrial dysfunctionOxidative stressSpermTestosterone

Identifiers

PMID41168547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.