Evidence map›Paper›PMID 41168490›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the ALBICS trial.

Akseli Talvasto, Peter Raivio, Minna Ilmakunnas, Erika Wilkman, Liisa Petäjä, Hanna Vlasov, Raili Suojaranta, Seppo Hiippala, Otto Helve, Tatu Juvonen and 1 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Akseli TalvastoDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. akseli.talvasto@helsinki.fi.ORCID 0000-0002-8451-3916
Peter RaivioDepartment of Cardiac Surgery, Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Minna IlmakunnasDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Erika WilkmanDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Liisa PetäjäDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hanna VlasovDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Raili SuojarantaDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Seppo HiippalaDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Otto HelveChildren's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tatu JuvonenDepartment of Cardiac Surgery, Heart and Lung Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eero PesonenDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

Non-US Government Research Support
6 · The paper itself

Abstract

purposeFibrinogen is widely used in cardiac surgery. Still, reported associations between plasma fibrinogen level and chest tube drainage are weak. The results of trials on fibrinogen supplementation are contradictory. We aimed to investigate how the plasma fibrinogen level relates to severe bleeding and resternotomy for bleeding in patients undergoing on-pump cardiac surgery.

methodsWe conducted an observational post hoc study of 1,386 patients undergoing on-pump cardiac surgery enrolled in the Albumin in Cardiac Surgery (ALBICS) trial. We assessed severe bleeding with the Universal Definition of Perioperative Bleeding classification (UDPB), categorized as "UDPB-low" (classes 0-2) and "UDPB-high" (classes 3-4) and as resternotomy. We measured plasma fibrinogen levels preoperatively and 30 min after protamine administration ("post-cardiopulmonary bypass [CPB]").

resultsThe incidences of UDPB-high and resternotomy were 8.1% (112/1,386) and 3.6% (50/1,386). No patient with preoperative a fibrinogen level > 4.7 g·L

conclusionThe preoperative fibrinogen level had borderline and the post-CPB fibrinogen level had strong associations with severe bleeding and resternotomy in patients undergoing on-pump cardiac surgery. Further research is required to delineate whether the observed association represents a cause-and-effect relationship.

Indexed as

Cardiac Surgical ProceduresFibrinogenPostoperative HemorrhageAgedCardiopulmonary BypassFemaleHumansMaleMiddle AgedProtaminesSeverity of Illness IndexFibrinogenProtaminesbleedingcardiac surgerycardiopulmonary bypassfibrinogen

Identifiers

PMID41168490
PMCPMC12680795

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.