ArticleNature plants2025
Natural variation in ZmDapF1 enhances maize drought resilience.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Achieving High-Density and Stress-Resilient Maize Breeding Via Germplasm Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Article
- Genome-Wide Study of MYB Transcription Factors in Maize and Their Essential Roles in Male Fertility and Other Biological Processes.International journal of molecular sciences · 2026Article
- CQD: A Rapid and Accurate Tool for Identifying High-Confidence QTLs and Candidate Genes from GWAS Summary Statistics.International journal of molecular sciences · 2026Article
- Identification of metabolic pathways associated with cytoplasmic male sterility in cotton (Gossypium hirsutum L.) using Data-Independent Acquisition-based proteomic profiling.BMC plant biology · 2026Article
- Plant domestication revisited: Genomic insights into origins, mechanisms, and convergent evolution.iScience · 2026Review
- Digital health technology empowering China's community full life cycle health management.Digital healthReview
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18 authors.
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Abstract
As drought severely threatens the stability of crop yields, it is crucial to develop cultivars with enhanced drought resilience. Here we demonstrate that natural variation in ZmDapF1, encoding a putative diaminopimelate epimerase, contributes to maize drought-stress resistance without compromising grain yield. ZmDapF1 inhibits the activity of ZmMDH6, a chloroplast NADP-dependent malate dehydrogenase. ZmDapF1 gene knockout mutants exhibited significantly enhanced seedling viability and grain yield under drought stress, while maintaining high yields under normal field conditions. Natural variations in the ZmDapF1 promoter increase its binding affinity to a MYB transcription factor, ZmMYB121, which represses ZmDapF1 expression under drought. Therefore, ZmMYB121 plays a positive role in drought resistance. Knocking out ZmDapF1 resulted in increased ZmMDH6 activity, enhanced photosynthetic rate and reduced reactive oxygen species accumulation under drought, which may confer the enhanced drought resilience. Thus, genetic engineering targeting ZmDapF1 holds great potential for developing maize varieties with improved drought resilience.
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