ReviewJournal of neurology2025
Sleep deprivation and risk for Parkinson's disease: evidence and therapeutic implications.
Review in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuronal degeneration in the substantia nigra, largely driven by misfolded protein aggregation. Sleep deprivation has emerged as a significant risk factor for neurological disorders, accelerating protein misfolding and dopaminergic neuronal loss through multiple pathological pathways. In this narrative review, we synthesize current evidence linking sleep deprivation to PD. We first outline epidemiological findings that support an association between insufficient sleep and increased PD risk. Building on these mechanisms, we review potential therapeutic strategies, such as behavioral and lifestyle modifications, circadian rhythm regulation, and targeted strategies addressing specific pathological pathways. Together, these insights underscore the importance of sleep in PD prevention and highlight opportunities for developing sleep-based precision therapies.
Indexed as
Identifiers
41168406What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.