Evidence map›Paper›PMID 41168395›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

First-in-human study of a novel bifunctional PET tracer [

Jie Zang, Hongfei Cheng, Yang Luo, Wenbin Jin, Yuxin Lai, Qingming Zheng, Yumeng Peng, Hank F Kung, Lin Zhu, Chunlin Ke and 2 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06688305 (68Ga-NI-FAPI PET/CT), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06688305 early_phase1recruitingnot on this map

68Ga-NI-FAPI PET/CT: First-in-human Study in Patients With Various Cancers

TypeinterventionalSponsorFirst Affiliated Hospital of Fujian Medical UniversityRan2024 to 2025Enrolled40ConditionsMalignant NeoplasmArms68Ga-NI-FAPI
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie Zang *Department of Nuclear Medicine, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fujian Province, Fuzhou, 350212, China.
Hongfei Cheng *Department of Nuclear Medicine, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fujian Province, Fuzhou, 350212, China.
Yang Luo *College of Chemistry, Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing, 100875, China.
Wenbin JinCollege of Chemistry, Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing, 100875, China.
Yuxin LaiDepartment of Nuclear Medicine, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fujian Province, Fuzhou, 350212, China.
Qingming ZhengSchool of Medical Imaging, Fujian Medical University, Fujian Province, Fuzhou, 350122, China.
Yumeng PengDepartment of Nuclear Medicine, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fujian Province, Fuzhou, 350212, China.
Hank F KungDepartment of Radiology, University of Pennsylvania, PA, Philadelphia, 19104, USA.
Lin ZhuCollege of Chemistry, Key Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing, 100875, China.
Chunlin KeDepartment of Radiotherapy, the First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fujian Province, Fuzhou, 350005, China. 296200383@fjmu.edu.cn.
Chen LiuDepartment of Oncology, the First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fujian Province, Fuzhou, 350005, China. 175696700@qq.com.
Weibing MiaoDepartment of Nuclear Medicine, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fujian Province, Fuzhou, 350212, China. miaoweibing@126.com.ORCID 0000-0002-0058-4953

Funding

Fujian Medical University Undergraduate Innovation and Entrepreneurship Training Program Project C2025222Fujian Provincial Clinical Key Specialty Construction Project 2023SZDZK-HYXKNational Natural Science Foundation of China 82202200National Natural Science Foundation of China 82472012the Innovation of Science and Technology of Fujian Province 2021Y9134the Innovation of Science and Technology of Fujian Province 2023Y9056
6 · The paper itself

Abstract

purposePreclinical studies have demonstrated that [

methodsA total of 50 patients underwent paired [

resultsThe effective absorbed dose of [

conclusion[

trial registrationClinicalTrials.gov, NCT06688305, Registered 14 November 2024, retrospectively registered.

Indexed as

GelatinasesMembrane ProteinsNitroimidazolesOrganometallic CompoundsPositron Emission Tomography Computed TomographyRadiopharmaceuticalsSerine EndopeptidasesTumor HypoxiaAdultAgedCoordination ComplexesEndopeptidasesFemaleGallium RadioisotopesHumansMaleCoordination ComplexesEndopeptidasesGallium-68Gallium RadioisotopesGelatinasesMembrane ProteinsNitroimidazolesOrganometallic CompoundsRadiopharmaceuticalsSerine EndopeptidasesFAPIHypoxiaNitroimidazolePET/CT

Identifiers

PMID41168395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.