Evidence map›Paper›PMID 41168281›Full record

ArticleScientific reports2025

Neuroprotective effects of Pycnogenol on nerve regeneration and functional recovery after sciatic nerve crush injury in rodents.

Bhavani R Nayak, Nanda Acharya, Dhiren Punja, Akash Tomar, Ashwath M Acharya, Rohini Punja, Nihaal Maripini, Rathi Bishakha Jayprakash

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bhavani R NayakDepartment of Physiology , Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal, India.
Nanda AcharyaDepartment of Physiology , Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal, India. nanda.acharya@manipal.edu.
Dhiren PunjaDepartment of Physiology , Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal, India. dhiren.punja@manipal.edu.
Akash TomarDepartment of Physiology , Kasturba Medical College, Manipal, Manipal Academy of Higher Education , Manipal, India.
Ashwath M AcharyaDepartment of Hand surgery , Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Rohini PunjaDepartment of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Nihaal MaripiniDepartment of Biochemistry , Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Rathi Bishakha JayprakashDepartment of Pharmacology , Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pycnogenol, a standardized French maritime pine bark extract, is known for its antioxidant, anti-inflammatory, and neuroprotective properties. This study evaluated its therapeutic potential in sciatic nerve regeneration following crush injury in female Sprague Dawley rats. Twenty-one rats were assigned to Sham, Control, and Pycnogenol (100 mg/kg/day) groups. After standardized nerve injury, Pycnogenol was administered for 28 days. Functional recovery was assessed using the Sciatic Functional Index (SFI), pinprick, and cold allodynia tests. Histopathology, muscle weight, and ELISA for nerve growth factor (NGF) were evaluated post-euthanasia. By Day 14, the Pycnogenol group showed significantly better SFI scores (83.60 ± 2.26 vs. 89.81 ± 2.42, p < 0.001), with continued improvement through Day 28 (49.42 ± 3.0 vs. 62.95 ± 2.93, p < 0.001). Histological analysis revealed enhanced muscle regeneration, increased fiber area, and improved myelination. ELISA confirmed significantly elevated NGF levels, supporting Pycnogenol's neuroprotective role. These findings highlight its potential in peripheral nerve injury treatment. Further research is needed to confirm efficacy in humans, explore molecular mechanisms, and compare it with existing neuro-regenerative therapies. Pycnogenol may serve as a promising agent in neurology and regenerative medicine.

Indexed as

FlavonoidsNerve RegenerationNeuroprotective AgentsPeripheral Nerve InjuriesAnimalsFemaleHyperalgesiaNerve CrushPlant ExtractsRatsRats, Sprague-DawleyFlavonoidsNeuroprotective AgentsPlant ExtractspycnogenolsNeuroprotectionPeripheral nerve injuryPycnogenolSciatic nerve crush injurySciatic nerve regenerationSprague Dawley rats

Identifiers

PMID41168281
PMCPMC12575757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.