ArticleNature communications2025
Vinyl-aza-[3]cumulene intermediates induced polymerization for accessing E-dienyl poly(sulfonylamidines) towards pH-responsive drug delivery.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Azetidinylideneketenimines as a Multimodal Synthetic Platform: Coordination Chemistry and Cycloaddition-Triggered Transformations.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
The development of reactive intermediates is very significant to construct functional compounds and polymers for multicomponent reactions and multicomponent polymerizations. Heterocumulenes as unique intermediates could be used for the rapid construction of diverse structural skeletons. In this work, a copper-catalyzed multicomponent reaction and polymerization of yne-allylic esters, amines, and azides was disclosed involving so-far unrecognized vinyl alkylidene ketenimine intermediates. Various poly(dienyl-N-sulfonylamidines) were excellently regio- (α-addition) and stereoselectively (E-exclusive) synthesized with molecular weights (7800-26,700 g/mol) and good thermal and chemical stability. Based on the self-assembly of polymers into nanoparticles in water, doxorubicin-loaded nanoparticles (DOX-NPs) were successfully prepared for drug delivery. The drug release results revealed that the DOX-NPs owned sensitive pH-responsive characteristics.
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