ArticleScientific reports2025
In vivo subcutaneous biocompatibility evaluation of decellularized tilapia fish skin in a rat model.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Propolis-functionalized acellular fish skin scaffolds as biotechnological platforms for antimicrobial activity and regenerative wound healing.BMC biotechnology · 2026Article
- Construction of an In Vitro Blood-Brain Barrier Micro-Organoid Model Using Decellularized Squid Mantle Scaffold Film.Journal of functional biomaterials · 2026Article
- Physical decellularization of fish skin utilizing electrical fields.Regenerative biomaterials · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decellularized tilapia fish skin (DTFS) has emerged as a promising biocompatible implant for wound healing due to its high collagen content, retained extracellular matrix (ECM) components, and structural similarity to human skin. This study investigates the decellularization of tilapia fish skin using two protocols including sodium dodecyl sulfate and sodium chloride (Treatment 1) and Triton X-100 and sodium hydroxide (Treatment 2) and evaluates their efficacy and biocompatibility. Decellularization efficiency was assessed through DNA quantification, histological analysis, and scanning electron microscopy. The DNA content in DTFS was significantly reduced (8.65 ± 1.25 ng/mg in Treatment 1 and 18.05 ± 0.85 ng/mg in Treatment 2) compared to native tilapia fish skin (286 ± 11 ng/mg), confirming effective removal of cellular material. Structural integrity of ECM was preserved in both treatments. In vivo biocompatibility was assessed by implanting the native and DTFS subcutaneously in Wistar rats, followed by hematological, biochemical (Urea, ALT, ALP, and LDH), and histological analysis of skin and liver tissues over 28 days. No significant abnormalities were observed in serum parameters or tissue morphology, indicating high biocompatibility. These results support the potential use of DTFS which are biocompatible as viable wound dressing for burn and chronic wound applications.
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