ReviewThe Journal of international medical research2025
The association between periodontitis and hypothyroidism: A comprehensive review.
Review in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review aimed to critically synthesize and evaluate the current evidence on the association between hypothyroidism and periodontitis, with a particular focus on elucidating the underlying pathophysiological mechanisms. A comprehensive literature search was conducted on PubMed, encompassing animal, cellular, and clinical studies. The synthesized findings indicate that hypothyroidism exacerbates periodontitis through multiple interconnected pathways, including dysregulated bone metabolism, induction of systemic osteoporosis, amplification of immune-inflammatory responses, and disruption of oral microbiome homeostasis. Furthermore, evidence suggests a potential bidirectional relationship, wherein periodontal therapy may positively influence thyroid function parameters. A key takeaway from this review is the importance of interdisciplinary collaboration between endocrinologists and dental professionals. Incorporating thyroid function evaluation into periodontal management may enhance treatment outcomes. This review concludes that although existing evidence supports a significant association, further high-quality longitudinal human studies are required to definitively establish causality and elucidate the precise underlying molecular mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.