Evidence map›Paper›PMID 41168084›Full record

ArticleThe FEBS journal2026

Lysine demethylase 4A: from chromatin to centrosomes.

Anushka Sharma, Ruth M Kearney, Ciaran G Morrison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anushka SharmaCentre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Ruth M KearneyCentre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Ciaran G MorrisonCentre for Chromosome Biology, School of Biological and Chemical Sciences, University of Galway, Ireland.ORCID 0000-0003-2401-7029

Funding

Taighde Éireann-Research Ireland 23/FFP-A/11620
6 · The paper itself

Abstract

The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome. KDM4A interacts with centrosome proteins, and its loss or inhibition leads to centrosome amplification or fragmentation, which in turn perturbs mitosis and causes genome instability. These findings suggest a link between chromatin regulation and control of centrosome number, through the regulation of KDM4A-dependent lysine methylation.

Indexed as

CentrosomeChromatinJumonji Domain-Containing Histone DemethylasesAnimalsHistonesHumansLysineMethylationMitosisChromatinHistonesJumonji Domain-Containing Histone DemethylasesKDM4A protein, humanLysinecentriolecentrosomechromatingenome stabilitylysine demethylationmitosis

Identifiers

PMID41168084
PMCPMC12820595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.