Evidence map›Paper›PMID 41168073›Full record

ArticleEBioMedicine2025

Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.

Moritz Gerster, Gunnar Waterstraat, Thomas S Binns, Natasha Darcy, Christoph Wiest, Richard M Köhler, Jojo Vanhoecke, Timothy O West, Matthias Sure, Dmitrii Todorov and 23 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  4. Article
  5. Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Moritz GersterDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany. Electronic address: mogerster@cbs.mpg.de.
Gunnar WaterstraatNeurophysics Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Thomas S BinnsBernstein Center for Computational Neuroscience, Berlin, Germany; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany; Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Natasha DarcyMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Christoph WiestMRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.
Richard M KöhlerMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Jojo VanhoeckeBernstein Center for Computational Neuroscience, Berlin, Germany; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Timothy O WestDepartment of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK; Department of Bioengineering, Sir Michael Uren Hub, Imperial College London, London, W12 0BZ, UK.
Matthias SureInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Dmitrii TodorovInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; The Biomedical Imaging Laboratory INSERM U1146, CNRS UMR 7371, Sorbonne University, 15 Rue de l'Ecole de Médecine, 75006, Paris, France.
Lukasz RadzinskiBernstein Center for Computational Neuroscience, Berlin, Germany; Neurophysics Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Jeroen HabetsMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Johannes L BuschMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Lucia K FeldmannMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Patricia KrauseMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Katharina FaustDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Gerd-Helge SchneiderDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Keyoumars AshkanDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, SE5 9RS, UK.
Erlick PereiraCity St George's, University of London & St George's University Hospitals NHS Foundation Trust, London, SW17 0QT, UK.
Harith AkramUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Ludvic ZrinzoUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Benjamin BlankertzNeurotechnology Group, Technische Universität Berlin, Berlin, Germany.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Huiling TanMRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jan HirschmannInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Andrea A KühnBernstein Center for Computational Neuroscience, Berlin, Germany; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Esther FlorinInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Alfons SchnitzlerInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Ashwini OswalMRC Brain Networks Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Vladimir LitvakDepartment of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK.
Wolf-Julian NeumannBernstein Center for Computational Neuroscience, Berlin, Germany; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Gabriel CurioBernstein Center for Computational Neuroscience, Berlin, Germany; Neurophysics Group, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Vadim NikulinDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease is linked to increased beta rhythms (13-30 Hz) in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies are inconsistent. Furthermore, the contribution of other frequencies to symptom severity remains underexplored.

methodsWe analysed subthalamic local field potentials from 119 patients with Parkinson's disease (31 female; mean age 60 ± 9 years) across five independent datasets. Power spectra were parametrised and studied in relation to Levodopa administration and the severity of motor symptoms.

findingsOur findings suggest that small sample sizes contributed to the variable correlations between beta power and motor symptoms reported in previous studies. Here, we demonstrate that more than 100 patients are required for stable replication. Aperiodic offset and low gamma (30-45 Hz) oscillations were negatively correlated with motor deficits (r

interpretationSpectral features beyond conventional beta rhythms are critical to understanding Parkinson's pathophysiology. Aperiodic broadband power shows potential as a new biomarker for adaptive deep brain stimulation, providing important insights into the relationship between subthalamic hyperactivity and motor symptoms in Parkinson's disease.

fundingThis work was supported by Deutsche Forschungsgemeinschaft (German Research Foundation) Project ID 424778381 TRR 295 "ReTune". H.A. is supported by NIHR UCLH BRC. This work was supported by an MRC Clinician Scientist Fellowship (MR/W024810/1) held by A.O. W.-J.N. received funding from the European Union (ERC, ReinforceBG, project 101077060). E.F. received funding from the Volkswagen foundation (Lichtenberg program 89387). G.W. and L.R. received funding from Deutsche Forschungsgemeinschaft Project ID 511192033.

Indexed as

Beta RhythmParkinson DiseaseSubthalamic NucleusAgedCross-Sectional StudiesDeep Brain StimulationFemaleHumansLevodopaMaleMiddle AgedSeverity of Illness IndexLevodopa1/f activityBasal gangliaMovement disordersNeurodegenerative disordersReproducibilitySpectral parameterization

Identifiers

PMID41168073
PMCPMC12790593

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