ArticleIn vivo (Athens, Greece)
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe optimal extent of neck dissection (ND) in oral squamous cell carcinoma (OSCC) is controversial, particularly regarding levels IV and V in cases with metastases in levels I-III. This study evaluated the probability of metastases in levels IV-V when levels I-III are pN+ in cN0 necks and analyzes prognostic factors influencing their occurrence. PATIENTS AND
methodsA retrospective study was performed at the Department of Oral, Maxillofacial and Facial Plastic Surgery, Ludwigshafen Hospital, Germany, including 61 patients with primary OSCC treated surgically including ND. Patients underwent either supraomohyoid ND (SOND) of levels I-III with secondary extension to IV-V or modified radical ND (MRND) of levels I-V. Statistical analysis assessed the correlation between metastases in levels IV-V and extracapsular spread (ECS), number of positive lymph nodes, T-classification, bone infiltration, grading, lymphovascular invasion, vascular invasion, and perineural invasion.
resultsAmong the 61 patients with metastases in levels I-III, 6 patients (9.8%) had metastases in levels IV-V. A significant correlation (
conclusionThe risk of level IV-V metastases in patients with pN+ in levels I-III exceeds 5% in cN0 necks. The number of affected nodes and pN classification were the strongest predictors. These findings support selective extension of ND beyond level III in specific patients and emphasize individualized treatment strategies.
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