ArticleIn vivo (Athens, Greece)
Preoperative Liver Function as a Predictor of Postoperative Liver Failure in Perihilar Cholangiocarcinoma.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Surgical Safety after Preoperative Chemotherapy for Perihilar Cholangiocarcinoma: Multi-Institutional Propensity-Matched Analysis.Annals of surgical oncology · 2026Observational
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimOperative mortality following surgical intervention for perihilar cholangiocarcinoma (PHCC) is attributable to clinically relevant liver failure (CRLF). Nonetheless, the risk factors for CRLF in patients undergoing preoperative portal vein embolization (PVE) remain undetermined. This study aimed to investigate the risk factors for CRLF following major hepatectomy with PVE in patients with PHCC. PATIENTS AND
methodsWe retrospectively assessed patients with PHCC. Post PVE, a value for rate of plasma disappearance of indocyanine green×residual liver volume (%) (ICGKF) ≥0.05 warranted curative resection.
resultsIn total, 346 patients were reviewed. CRLF developed in 27.5% of the patients. Operative time >660 min, blood loss >1,900 ml, and procedures other than left hepatectomy were independent risk factors for CRLF. Subsequently, 167 patients undergoing PVE were included in the analysis. Pre-PVE ICGKF <0.05, long operative time, and high intraoperative bleeding were independent risk factors for CRLF. The mortality rate for patients with all three risk factors was 25%. The incidence of CRLF after hepatectomy with extended bile duct resection for perihilar cholangiocarcinoma was 27.5%.
conclusionProlonged surgery, and high blood loss are associated with an elevated mortality rate following PHCC surgery, particularly when accompanied by low pre-PVE ICGKF.
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