ArticleIn vivo (Athens, Greece)
The Influence of Blood Glucose Instability on Aortic Health in Diabetes: Evaluating the Role of G-CSF Therapy.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
BACKGROUND/
aimTo evaluate the adverse effects of glucose fluctuations on the aorta in diabetic rats and to investigate the potential therapeutic role of granulocyte colony-stimulating factor (G-CSF). MATERIALS AND
methodsThirty-nine adult male albino rats (10-12 weeks old, 150-180 g) were divided equally into three groups: diabetic, control, and Filgrastim (a human G-CSF)-treated. Diabetes was induced using alloxan in the diabetic and Filgrastim groups. The Filgrastim-treated group received intraperitoneal glucose injections every four hours for four days, followed by subcutaneous Filgrastim (200 μg/kg/day) for five days. Histological analysis of aortic sections was conducted using Hematoxylin and Eosin staining.
resultsSignificant differences were observed between groups in insulin levels (
conclusionGlucose fluctuations caused more severe endothelial damage in the aorta of diabetic rats compared to controls. G-CSF shows promise as a potential therapy for cardiovascular complications associated with fluctuating hyperglycemia.
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