Evidence map›Paper›PMID 41167689›Full record

Observational studyIn vivo (Athens, Greece)

Marked Increase in Zinc Concentration of Ascitic Fluid After Cell-free and Concentrated Ascites Reinfusion Therapy in Patients With Cirrhotic Refractory Ascites: A Retrospective Observational Study.

Tadashi Namisaki, Akihiko Shibamoto, Satoshi Iwai, Masayoshi Takami, Hiroyuki Masuda, Yuki Tsuji, Yukihisa Fujinaga, Hiroaki Takaya, Takashi Inoue, Shinya Sato and 6 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tadashi NamisakiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan; tadashin@naramed-u.ac.jp.
Akihiko ShibamotoDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Satoshi IwaiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Masayoshi TakamiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Hiroyuki MasudaDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Yuki TsujiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Yukihisa FujinagaDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Hiroaki TakayaDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Takashi InoueDepartment of Evidence-Based Medicine, Nara Medical University, Kashihara, Japan.
Shinya SatoDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Koh KitagawaDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Norihisa NishimuraDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Kosuke KajiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Akira MitoroDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.
Kiyoshi AsadaClinical Research Center, Nara Medical University, Nara Medical University, Kashihara, Japan.
Hitoshi YoshijiDepartment of Gastroenterology, Nara Medical University, Kashihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimZinc (Zn) deficiency is common among patients with cirrhosis and is associated with hepatic encephalopathy, immune dysfunction, and sarcopenia. In Japan, cell-free and concentrated ascites reinfusion therapy (CART) is widely employed for refractory ascites, effectively restoring albumin (ALB) and coagulation factors. However, its effect on trace elements has not been investigated. This retrospective study aimed to assess Zn concentration changes in ascitic fluid before and after CART in patients with cirrhotic refractory ascites. PATIENTS AND

methodsData from 24 patients with decompensated cirrhosis who underwent CART at Nara Medical University Hospital between June 2022 and May 2024 were analyzed. The concentrations of Zn and ALB in original and processed ascitic fluid were measured.

resultsAmong the cohort (mean age, 66.3±13.7 years, 69.6% men), 75.0% had Child-Pugh class C cirrhosis. The mean volume of drained ascitic fluid was 5,947.2±2,345.9 ml, whereas that of processed ascitic fluid was 350.6±167.6 ml. Positive correlations were observed between serum Zn and serum albumin (ALB) levels as well as ascitic Zn and ascitic ALB levels. The Zn concentration significantly increased from 12 μg/dl in the original ascitic fluid to 119 μg/dl in the processed ascitic fluid (

conclusionCART markedly increases Zn concentration in ascitic fluid, which may contribute to the restoration of micronutrient levels in patients with cirrhosis. Further studies should determine whether reinfusion of Zn-rich processed ascitic fluid increases serum Zn levels and enhances clinical outcomes.

Indexed as

AscitesAscitic FluidLiver CirrhosisZincAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSerum AlbuminTreatment OutcomeSerum AlbuminZincCARTCirrhosismicronutrientsrefractory ascitestrace elementszinc

Identifiers

PMID41167689
PMCPMC12588221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.