ArticleIn vivo (Athens, Greece)
Polysaccharides Derived from
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimAging results in diminished physiological functions and reduced stem cell activity, driving research into cellular mechanisms and natural compounds that support tissue regeneration and improve skin health. Marine algae, particularly MATERIALS AND
methodsThe expression levels of stem cell transcription factors were evaluated at the mRNA level using RT-qPCR and at the protein level
resultsThe findings revealed that treatment with sea grape significantly enhanced the expression of stem cell transcription factors in human Dermal Papilla (DP) cells, with mRNA levels of OCT4, NANOG, and SOX2 increasing by 20-, 35-, and 15-fold, respectively. Likewise, in UE6E7T-3 bone marrow stem cells, sea grape induced OCT4, NANOG, and SOX2 induction by 1.5-, 1.5-, and 2.5-fold, respectively. Corresponding protein levels of these stem cell markers also showed increased expression in both sea grape-treated DP cells and UE6E7T-3 cells. Additionally, sea grape exhibited a significant anti-melanogenic effect on human melanoma cells.
conclusionOverall, sea grape reduces melanin levels and stimulates regenerative markers in stem cells, presenting a promising opportunity for developing novel products focused on pigmentation regulation and skin rejuvenation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.