Evidence map›Paper›PMID 41167669›Full record

ArticleIn vivo (Athens, Greece)

Patterns of Recurrence and Malignant Transformation in Sinonasal Papilloma: Implications for Long-term Follow-up.

Takayuki Kimura, Satoru Koike, Hisatomo Tamaki, Kazuhiro Miyamoto, Shusuke Iwamoto, Noriko Ohira, Daisuke Abe, Mitsuo Sato, Mutsukazu Kitano, Takahiro Wakasaki and 1 more

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In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takayuki KimuraDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Satoru KoikeDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Hisatomo TamakiDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Kazuhiro MiyamotoDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Shusuke IwamotoDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Noriko OhiraDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Daisuke AbeDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Mitsuo SatoDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Mutsukazu KitanoDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Takahiro WakasakiDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.
Ryuji YasumatsuDepartment of Otolaryngology-Head and Neck Surgery, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan ryuji.yasumatsu@med.kindai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimSinonasal papilloma is a histologically benign tumor that demonstrates locally aggressive behavior, with a propensity for recurrence and potential for malignant transformation. This study aimed to evaluate the clinical characteristics, recurrence patterns, and malignant transformation of sinonasal papillomas and to propose appropriate follow-up strategies. PATIENTS AND

methodsA retrospective analysis was conducted on 83 patients diagnosed with sinonasal papilloma at our institution. Clinical features, surgical treatments, recurrence intervals, and oncologic outcomes were analyzed. Tumors were staged using the Krouse classification for benign cases and UICC TNM staging for carcinoma-associated with papilloma cases.

resultsAmong 83 patients (62 men, 21 women; median age 68), 74 (89.2%) were diagnosed as benign papillomas and nine (10.8%) as carcinoma-associated with papilloma. The recurrence rate among benign cases was 14.9% (11/74), with a median time to recurrence of 5 years and two months. Recurrence intervals exhibited a trimodal distribution: within two years (36.4%), between 2-10 years (36.4%), and after 10 years (27.3%). Malignant transformation occurred in one case (1.2%), and eight additional cases were found to be associated with carcinoma. Five of these were initially misdiagnosed as benign, underscoring the diagnostic limitations of imaging modalities. Krouse T3/T4 lesions were more frequently associated with recurrence and malignancy. Approximately 48.6% of patients discontinued follow-up, often before reaching the threshold for late recurrence.

conclusionSinonasal papillomas require long-term surveillance beyond five years due to their potential for late recurrence and malignant transformation. Preoperative suspicion of malignancy remains challenging, particularly in Krouse T3 lesions. Clinicians should consider extended follow-up, especially in patients with advanced tumor stage, and adopt a tailored surgical strategy to achieve complete resection. Patient education regarding recurrence risk is essential for optimizing long-term outcomes.

Indexed as

Cell Transformation, NeoplasticNeoplasm Recurrence, LocalPapillomaParanasal Sinus NeoplasmsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingRetrospective Studiesinverted papillomalong-term follow-upmalignant transformationrecurrenceSinonasal papillomasquamous cell carcinoma

Identifiers

PMID41167669
PMCPMC12588194

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.