Evidence map›Paper›PMID 41167666›Full record

ArticleIn vivo (Athens, Greece)

Effect of Decay-accelerating Factor on LPS-induced Acute Lung Injury in the Rat.

Maria G Detsika, Ioanna Nikitopoulou, Stylianos E Orfanos, Ioanna Dimopoulou, Anastasia Kotanidou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria G Detsika1 Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece mdetsika@med.uoa.gr.
Ioanna Nikitopoulou1 Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Stylianos E Orfanos1 Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Ioanna Dimopoulou1 Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Anastasia Kotanidou1 Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece akotanid@med.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimComplement activation has been implicated as a contributor to lung injury. Membrane-bound complement regulatory proteins, including decay-accelerating factor (DAF), control complement activation, thus mitigating complement-mediated injury. Their effect on lung injury remains unexplored. Using a DAF knockout rat model, we assessed the effect of DAF on the extent of lipopolysaccharide (LPS)-mediated acute lung injury (ALI) in rats. MATERIALS AND

methodsWild-type (WT) and DAF-knock out (

resultsLPS administration to WT rats caused histopathological lesions indicative of ALI and significantly increased infiltrating inflammatory cells, as well as total number of cells and interleukin (IL)-6 levels, in bronchoalveolar lavage fluid samples. DAF absence resulted in increased C3b levels in

conclusionDAF deficiency increased baseline C3b and C5aR1 protein levels in lung tissue. LPS-induced inflammatory response and lung injury were augmented in

Indexed as

Acute Lung InjuryCD55 AntigensLipopolysaccharidesAnimalsComplement ActivationComplement C3bCytokinesDisease Models, AnimalLungMaleRatsReceptor, Anaphylatoxin C5aCD55 AntigensComplement C3bCytokinesLipopolysaccharidesReceptor, Anaphylatoxin C5aacute lung injuryComplement regulationLPS

Identifiers

PMID41167666
PMCPMC12588219

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.