Evidence map›Paper›PMID 41167662›Full record

ArticleIn vivo (Athens, Greece)

Comparison of Survival Outcomes and Toxicities Between Volumetric-modulated Arc Therapy and Conventional Radiotherapy in Early Glottic Cancer.

Hyeon Kang Koh, Younghee Park, Taeryool Koo, Kwang-Ho Cheong, Me Yeon Lee, Hae Jin Park, Kyoung Ju Kim, Soah Park, Taejin Han, Sei-Kwon Kang and 4 more

Abstract readComparative Study
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hyeon Kang Koh *Department of Radiation Oncology, Konkuk University School of Medicine and Konkuk University Medical Center, Seoul, Republic of Korea.
Younghee Park *Department of Radiation Oncology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Taeryool KooDepartment of Radiation Oncology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea; kootaeryool@hallym.or.kr.
Kwang-Ho CheongDepartment of Radiation Oncology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea.
Me Yeon LeeDepartment of Radiation Oncology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea.
Hae Jin ParkDepartment of Radiation Oncology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Kyoung Ju KimDepartment of Radiation Oncology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Soah ParkDepartment of Radiation Oncology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Taejin HanDepartment of Radiation Oncology, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.
Sei-Kwon KangDepartment of Radiation Oncology, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.
Boram HaDepartment of Radiation Oncology, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea.
Jai-Woong YoonDepartment of Radiation Oncology, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, Republic of Korea.
Me Young KimDepartment of Radiation Oncology, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Republic of Korea.
Hoonsik BaeDepartment of Radiation Oncology, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Gangwon-do, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo compare survival outcomes and radiation-related toxicities between conventional radiotherapy (CvT) and volumetric-modulated arc therapy (VMAT) in patients with early glottic cancer. PATIENTS AND

methodsWe reviewed 81 patients with Tis-T2N0 glottic cancer who underwent definitive radiotherapy between 2010 and 2018. CvT (N=47) was delivered using two opposing lateral beams (70 Gy in 35 fractions), while VMAT (N=34) utilized two arcs (65.25 Gy in 29 fractions). Hypothyroidism was defined as an elevated thyroid-stimulating hormone level with or without a decrease in free T4 or T3 levels.

resultsThe overall median follow-up time was 80.0 months and was longer in the CvT group (116.0 months) than in the VMAT group (45.3 months). Five-year local failure-free survival (95.4%

conclusionVMAT demonstrated comparable survival outcomes to CvT while significantly reducing the incidence of hypothyroidism and potentially lowering carotid artery events. VMAT may be considered a preferred modality to improve quality of life in patients with early glottic cancer.

Indexed as

Carotid StenosisGlottisHypothyroidismLaryngeal NeoplasmsRadiation InjuriesRadiotherapy, Intensity-ModulatedAdultAgedAged, 80 and overCarotid ArteriesFemaleFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateMaleThyrotropinThyroxineTriiodothyroninecarotid artery stenosisconventional radiotherapyEarly glottic cancerhypothyroidismvolumetric modulated arc therapy

Identifiers

PMID41167662
PMCPMC12588246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.