ArticleIn vivo (Athens, Greece)
Regulatory T-cell Activation Pathways in Patients With Chronic Graft-versus-host Disease Undergoing Extracorporeal Photopheresis Treatment: A Single-center Pilot Study.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Evolving Paradigms in Chronic Graft-Versus-Host Disease: From Global Immunosuppression to Precision Targeted and Cell-Based Therapies.Stem cell reviews and reports · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimInduction of immune tolerance by the activation of regulatory T (Tregs) cells after extracorporeal photopheresis (ECP) appears to influence the response to treatment in patients with chronic graft-versus-host disease (cGvHD). This study examined the activation mechanisms of Tregs and their potential link to the expression of MATERIALS AND
methodsThe study included six patients with cGvHD who underwent at least four cycles of ECP. The samples were collected from peripheral blood (PB) and from apheresis material before and after ECP, which was then used to establish cell cultures. The percentage of Tregs and their subpopulations were assessed using multicolor flow cytometry. Gene expression levels were evaluated using quantitative PCR (qPCR).
resultsA statistically significant increase in the expression levels of
conclusionPatients with PR demonstrated elevated gene expression levels in 48-h mononuclear cell cultures, which correlated with their clinical response to treatment. They also had a higher baseline percentage of Tregs, which did not correlate with elevated
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.