Evidence map›Paper›PMID 41167657›Full record

ReviewIn vivo (Athens, Greece)

Cancer Stem Cells and Endothelial Cells: An Ancient But Timeless Cooperation.

Domenico Ribatti, Anca Maria Cimpean

Abstract readReview
In one paragraph

Review in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Domenico RibattiDepartment of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy; domenico.ribatti@uniba.it.
Anca Maria CimpeanDepartment of Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania; ancacimpean1972@yahoo.com acimpeanu@umft.ro.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) are a highly tumorigenic cell population present in many malignancies and cancer cell lines, frequently exhibiting resistance to conventional chemotherapeutic agents. In this brief review, we discuss the ability CSCs to transdifferentiate into endothelial cells by expressing markers of the vascular endothelium. We highlight the similarities between mechanisms found in embryonic and tumor development, emphasizing mechanisms that enable CSCs to adopt an endothelial phenotype. Correlations with cellular and molecular mechanisms favoring CSC-to-endothelial transition, but also the impact on vasculogenic mimicry and antiangiogenic/antivascular drug resistance are also debated.

Indexed as

Endothelial CellsEndothelium, VascularNeoplasmsNeoplastic Stem CellsNeovascularization, PathologicAngiogenesis InhibitorsAnimalsAntineoplastic AgentsCell TransdifferentiationDrug Resistance, NeoplasmHumansAngiogenesis InhibitorsAntineoplastic AgentsAngiogenesiscancer stem cellsendothelial cellsreviewvasculogenic mimicry

Identifiers

PMID41167657
PMCPMC12588200

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.