Evidence map›Paper›PMID 41167395›Full record

ArticleJournal of lipid research2025

P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins.

Poonamjot Deol, Johannes Fahrmann, Dmitry Grapov, Jun Yang, Jane R Evans, Oliver Fiehn, Brett Phinney, Bruce D Hammock, Frances M Sladek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Poonamjot DeolDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, California, USA; Department of Microbiology and Plant Pathology, University of California, Riverside, California, USA. Electronic address: pdeol001@ucr.edu.
Johannes FahrmannDepartment of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Dmitry GrapovCDS - Creative Data Solutions, Colfax, California, USA.
Jun YangDepartment of Entomology and Nematology & UCD Comprehensive Cancer Center, University of California, Davis, California, USA.
Jane R EvansDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, California, USA.
Oliver FiehnGenome Center, University of California, Davis, California, USA.
Brett PhinneyGenome Center, University of California, Davis, California, USA.
Bruce D HammockDepartment of Entomology and Nematology & UCD Comprehensive Cancer Center, University of California, Davis, California, USA.
Frances M SladekDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, California, USA. Electronic address: frances.sladek@ucr.edu.

Funding

West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
Research Training in Environmental ToxicologyT32ES018827 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Yinsheng Wang · 2010 to 2026
$5.3M
REGULATION OF LIVER SPECIFIC GENE EXPRESSIONR01DK053892 · NIDDK · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SLADEK, FRANCES M. · 1998 to 2015
$5.3M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
Balance between HNF4a isoforms in the carbohydrate-lipid metabolic switchR01DK127082 · NIDDK · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SLADEK, FRANCES M. · 2021 to 2025
$2.0M
NIDDK NIH HHS R01 DK053892NIDDK NIH HHS R01 DK127082NIDDK NIH HHS U24 DK097154NIEHS NIH HHS R01 ES002710NIEHS NIH HHS T32 ES018827
6 · The paper itself

Abstract

Oxylipins-oxidized metabolites of polyunsaturated fatty acids (PUFAs)-are associated with several pathological conditions. We previously showed that oxylipin metabolites of linoleic acid (LA) and alpha-linolenic acid positively correlate with obesity in wild-type (WT) mice fed a high fat diet (35% kcal fat) based on soybean oil (SO). Here, we compare the effect of the SO diet (10% kcal LA) to an isocaloric diet based on coconut oil (CO) that is low in LA (2% kcal) in HNF4α exon swap male mice that express only the P2 form of HNF4α (α7HMZ). α7HMZ mice gained significantly less weight on the SO diet than WT mice and exhibited neither glucose intolerance nor fatty liver as did the WT mice. Untargeted metabolomics of the liver revealed increased levels of LA and decreased levels of PUFA-derived C18 diols in α7HMZ compared to WT. Proteomics identified decreased levels of several enzymes involved in PUFA metabolism (CYP2Cs, EPHX1, FADS2, ACOX1/2) as the likely cause of decreased diols. Correlation analysis of hepatic oxylipins with body weight, coupled with a 16-weeks treatment with a soluble epoxide inhibitor (sEHI), identified the oxylipins most likely to be potential drivers of obesity as 9,10-DiHOME, 12,13-DiHOME, 9,10-DiHODE and 12,13-DiHODE. Hepatic accumulation of omega-6 and omega-3 oxylipin metabolites of the essential fatty acids, linoleic and alpha-linolenic, are necessary but not sufficient for diet-induced obesity.

Indexed as

Hepatocyte Nuclear Factor 4Linoleic AcidObesityOxylipinsSoybean OilAnimalsLiverMaleMiceHepatocyte Nuclear Factor 4Linoleic AcidOxylipinsSoybean OilCYP450Epoxide HydrolasesHigh-Fat DietKetone BodiesMetabolic DiseaseMetabolomicsMitochondrial FunctionProinflammatory cytokinesProteomicsPUFAsTCA Cycle

Identifiers

PMID41167395
PMCPMC12743519

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.