Evidence map›Paper›PMID 41167286›Full record

ArticleBrain, behavior, and immunity2026

PTSD and suPAR: A multicohort investigation of chronic inflammation.

Kyle J Bourassa, Terrie E Moffitt, Louise Arseneault, Ashleigh Barrett-Young, Andrea Danese, Melanie E Garrett, Renate Houts, Timothy Matthews, Richie G Poulton, Sandhya Ramrakha and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Kyle J BourassaVA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System, Durham, NC, USA; Department of Psychology, Georgetown University, Washington D.C., Durham, NC, USA; Center for the Study of Aging and Human Development, Duke University Medical Center, USA. Electronic address: kyle.bourassa@duke.edu.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, the United Kingdom of Great Britain and Northern Ireland; Center for the Study of Population Health & Aging, Duke University Population Research Institute, USA.
Louise ArseneaultSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, the United Kingdom of Great Britain and Northern Ireland; ESRC Centre for Society and Mental Health, King's College London, the United Kingdom of Great Britain and Northern Ireland.
Ashleigh Barrett-YoungDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Andrea DaneseSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, the United Kingdom of Great Britain and Northern Ireland; Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, the United Kingdom of Great Britain and Northern Ireland; National and Specialist CAMHS Clinic for Trauma, Anxiety, and Depression, South London and Maudsley NHS Foundation Trust, London, the United Kingdom of Great Britain and Northern Ireland.
Melanie E GarrettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Renate HoutsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Timothy MatthewsSchool of Human Sciences, University of Greenwich, London, the United Kingdom of Great Britain and Northern Ireland.
Richie G PoultonDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Sandhya RamrakhaDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Stefan SprinckmollerSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, the United Kingdom of Great Britain and Northern Ireland.
Karen SugdenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Benjamin WilliamsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Jean C BeckhamVA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, the United Kingdom of Great Britain and Northern Ireland.
Allison E Ashley-KochDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Nathan A KimbrelVA Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Health Care System, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, the United Kingdom of Great Britain and Northern Ireland; VA Health Services Research and Development Center of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Health Care System, the United Kingdom of Great Britain and Northern Ireland.
Helen L FisherDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA; ESRC Centre for Society and Mental Health, King's College London, the United Kingdom of Great Britain and Northern Ireland.
Reremoana F TheodoreDunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, the United Kingdom of Great Britain and Northern Ireland; Center for the Study of Population Health & Aging, Duke University Population Research Institute, USA.
Line J H RasmussenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA; Department of Clinical Research, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.

Funding

Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Neuropsychological and genomic signatures of violence exposure in childhoodR01HD077482 · NICHD · DUKE UNIVERSITY · PI CASPI, AVSHALOM · 2013 to 2018
$2.8M
BLRD VA IK6 BX003777BLRD VA IK6 BX006523CSRD VA IK2 CX002694CSRD VA IK6 CX002767NIA NIH HHS R01 AG032282NICHD NIH HHS R01 HD077482
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) is associated with poor health. Prior research has shown stressful events are associated with inflammatory biomarkers, such as soluble urokinase plasminogen activator receptor (suPAR), suggesting systemic chronic inflammation could be a mechanism linking adversity to poor health. In this study, we examined associations of PTSD and suPAR in two research cohorts-the E-Risk Study (United Kingdom; n = 1,389) and the Dunedin Multidisciplinary Health and Development Study (New Zealand; n = 927)-and a clinical cohort of medical patients (Denmark; n = 29,285). We also present results from two commonly assessed inflammatory biomarkers: C-reactive protein (CRP) and interleukin-6 (IL-6). People with a lifetime history of PTSD had higher suPAR at age 18 in E-Risk (β = 0.21, p = 0.046) and age 38 in the Dunedin Study (β = 0.23, p = 0.025), but not age 45 in the Dunedin Study (β = 0.18, p = 0.050). Individuals who developed PTSD in the year prior to age 45 in Dunedin had significant increases in suPAR from age 38 to 45 (β = 0.45, p = 0.034). Danish patients with a recent diagnosis of PTSD or a stress-related psychiatric disorder had higher levels of suPAR compared to propensity score-matched patients without such diagnoses (0.10 < βs < 0.24, ps < 0.05). CRP and IL-6 did not show consistent associations with PTSD. These results suggest that PTSD is associated with suPAR and that systemic chronic inflammation could help explain how trauma and PTSD might result in poor health.

Indexed as

InflammationReceptors, Urokinase Plasminogen ActivatorStress Disorders, Post-TraumaticAdolescentAdultAgedBiomarkersChronic DiseaseCohort StudiesC-Reactive ProteinDenmarkFemaleHumansInterleukin-6MaleMiddle AgedBiomarkersC-Reactive ProteinInterleukin-6PLAUR protein, humanReceptors, Urokinase Plasminogen ActivatorCRPIL-6InflammationPTSDsuPARTrauma

Identifiers

PMID41167286
PMCPMC12648567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.