Evidence map›Paper›PMID 41167198›Full record

ArticleACS applied bio materials2025

Injectable ε-Polylysine/Hyaluronic Acid Hydrogels with Resistance-Preventing Antibacterial Activity for Treating Wound Infections.

Artemijs Sceglovs, Claudia Siverino, Ingus Skadins, Marika Sceglova, Valdis Pirsko, Thomas Fintan Moriarty, Juta Kroica, Kristine Salma-Ancane

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Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Artemijs SceglovsInstitute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena St. 3, Riga lv-1048, Latvia.
Claudia SiverinoAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.
Ingus SkadinsDepartment of Biology and Microbiology, Riga Stradins University, Dzirciema St. 16 Riga lv-1007, Latvia.
Marika SceglovaInstitute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena St. 3, Riga lv-1048, Latvia.
Valdis PirskoInstitute of Microbiology and Virology, Riga Stradins University, Ratsupites St. 5, Riga lv-1067, Latvia.
Thomas Fintan MoriartyAO Research Institute Davos, Clavadelerstrasse 8, Davos 7270, Switzerland.ORCID 0000-0003-2307-0397
Juta KroicaDepartment of Biology and Microbiology, Riga Stradins University, Dzirciema St. 16 Riga lv-1007, Latvia.
Kristine Salma-AncaneInstitute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Paula Valdena St. 3, Riga lv-1048, Latvia.ORCID 0000-0001-9215-0097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing threat of antimicrobial resistance has created an urgent demand for nonantibiotic biomaterials capable of preventing infections without promoting bacterial resistance. In this study, we developed injectable, covalently cross-linked hydrogels composed of ε-poly-l-lysine (ε-PL) and hyaluronic acid (HA) for localized wound infection treatment. These hydrogels combine the inherent antibacterial properties of ε-PL with the biocompatibility of HA, forming a shear-thinning, self-recovering system suitable for syringe-based administration. We first evaluated the antibacterial activity of pure ε-PL, determining minimum inhibitory and bactericidal concentrations (MIC/MBC) and evaluating resistance development against ATCC and clinically isolated multidrug-resistant strains (MRSA, ESBL-

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsHyaluronic AcidHydrogelsPolylysineWound InfectionAnimalsBiofilmsEscherichia coliHumansInjectionsMaterials TestingMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsBiocompatible MaterialsHyaluronic AcidHydrogelsPolylysineantibacterial hydrogelsantibiofilmhyaluronic acidmultidrug-resistant bacteriaresistance preventionε-polylysine

Identifiers

PMID41167198
PMCPMC12628331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.