Evidence map›Paper›PMID 41167051›Full record

ArticleMultiple sclerosis and related disorders2025

Significance of brain lesions associated with optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease.

Vivien X Xie, Haiwen Chen, Claire Har, Kyle Spagnolo, Melike Guryildirim, Ilana Kahn, Leigh Sepeta, Elias S Sotirchos, Alexandra B Kornbluh

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vivien X XieDivision of Neurology, Children's National Hospital, George Washington University Medical School, WA, District of Columbia, USA. Electronic address: vxie@childrensnational.org.
Haiwen ChenDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Claire HarDivision of Neurology, Children's National Hospital, George Washington University Medical School, WA, District of Columbia, USA.
Kyle SpagnoloDivision of Diagnostic Imaging and Radiology, Children's National Hospital, WA, District of Columbia, USA.
Melike GuryildirimDivision of Pediatric Radiology and Pediatric Neuroradiology, Johns Hopkins Hospital, Baltimore, MD, USA.
Ilana KahnDivision of Neurology, Children's National Hospital, George Washington University Medical School, WA, District of Columbia, USA.
Leigh SepetaDepartment of Neuropsychology, Children's National Hospital, WA, District of Columbia, USA.
Elias S SotirchosDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandra B KornbluhDivision of Neurology, Children's National Hospital, George Washington University Medical School, WA, District of Columbia, USA.

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
Prediction of risk of disability worsening and inflammatory disease activity in MS utilizing multimodal prediction algorithmsK23NS117883 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SOTIRCHOS, ELIAS S · 2020 to 2024
$918k
NINDS NIH HHS K12 NS098482NINDS NIH HHS K23 NS117883
6 · The paper itself

Abstract

backgroundOptic neuritis (ON) is a common presenting core clinical attack type in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and can be associated with brain lesions at presentation. The significance of these brain lesions and their contribution to disease course, however, are poorly understood.

methodsMulti-center retrospective chart review of clinical, laboratory, and radiologic data of pediatric MOGAD patients who presented with an ON phenotype.

results35 episodes of ON, including 29 new onset MOGAD attacks and 6 ON relapses, were analyzed among 32 total pediatric MOGAD patients (median age 12 years [range 3-18]; 69 % female). 20/35 (57 %) presented with ON without brain lesions and 15/35 (43 %) presented with ON and brain lesions. 11/15 (73 %) episodes of ON and brain lesions did not have ADEM. Clinically, 7/11 (64 %) were asymptomatic from the brain lesions; 2/11 (18 %) experienced seizures, and 2/11 (18 %) experienced focal neurologic deficits. Lesion morphology and distribution varied among episodes, with 7/11 (64 %) demonstrating small, non-specific, and non-confluent lesions on MRI. Patients in all groups at 3 months after presentation had a good outcome with a modified Rankin Score (mRS) of 0-2.

conclusionsMost brain lesions in pediatric MOGAD ON patients are clinically silent, small, and non-specific. Patients with ON and brain lesions did not have worse mRS outcomes compared to patients with ON without brain lesions. Further investigation of paraclinical data and more sensitive outcome measures will help elucidate pathophysiologic differences between these phenotypes and help guide prognostication.

Indexed as

BrainMyelin-Oligodendrocyte GlycoproteinOptic NeuritisAdolescentAutoantibodiesChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseRetrospective StudiesAutoantibodiesMyelin-Oligodendrocyte GlycoproteinBrain lesionsDemyelinationMOGADOptic neuritis

Identifiers

PMID41167051
PMCPMC13067371

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