Evidence map›Paper›PMID 41166733›Full record

ArticleOrganic letters2025

Expanding Peptide Chemical Space via Acid-Mediated Arginine Modification.

Pinki Sihag, Minyoung Kwon, Ankita Misra, Monika Raj

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pinki SihagDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Minyoung KwonDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Ankita MisraDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Monika RajDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0001-9636-2222

Funding

Chemistry for next-generation single-molecule fluorosequencing technology 2.0.R01HG012941 · NHGRI · EMORY UNIVERSITY · PI RAJ, MONIKA · 2023 to 2023
$2.1M
NHGRI NIH HHS R01 HG012941
6 · The paper itself

Abstract

We describe an acid-mediated chemoselective method for the targeted modification of arginine residues in peptides. Malonaldehyde efficiently converts guanidinium side chains into amino pyrimidine moieties with near-quantitative conversion across diverse substrates. Side products are reversible with butylamine, underscoring the method's robustness. The resulting amino pyrimidine peptides exhibit enhanced cellular permeability and allow late-stage diversification into imidazo[1,2-

Indexed as

ArgininePeptidesPyrimidinesMolecular StructureArgininePeptidesPyrimidines

Identifiers

PMID41166733
PMCPMC12624831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.