ArticleAnnals of medicine2025
Infectious complications in Philadelphia-Negative adolescent and young adult acute lymphoblastic leukemia patients in the era of pediatric-inspired regimen.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPediatric acute lymphoblastic leukemia (ALL) has a cure rate above 90%, but outcomes in adult remain poor, with 3-year survival around 40%. Adolescents and young adults (AYAs) fall between these groups, often facing worse disease features and treatment-related risks. While pediatric-inspired regimens improve survival in AYAs, they also raise the issue of infection due to treatment intensity.
methodsA retrospective analysis was conducted on AYA-ALL patients treated at Chiang Mai University Hospital from 1 January 2007 to 31 December 2023. Data were accessed for research purpose from 10 January 2024 to 31 December 2024. Patients received either pediatric-inspired (TPOG) or adult regimens (Hyper-CVAD or GMALL). Infections were classified as clinically (CDI) or microbiologically documented (MDI). Logistic regression identified infection risk factors.
resultsAmong 94 patients (62.8% male; median age 22.9 years), 56.4% received TPOG and 43.6% adult regimens. Infections occurred in 79.8%, higher with adult regimens (90.2% vs. 71.7%,
conclusionAYA-ALL patients are highly susceptible to infections, particularly with adult regimens. Fungal infections were more frequent with TPOG. Strengthening infection prevention and providing early treatment are vital.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.