Observational studyEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025
The SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0): an analysis of European S-ICD clinical practice and its evolution in paediatric patients.
Massimo Stefano Silvetti, Luc Bruyndonckx, Victor Waldmann, Roman Gebauer, László Környei, Tomasz Ksiazczyk, Vieira Illikova, Terezia Tavacova, Ferran Roses-Noguer, Joanna Kwiatkowska and 18 more
Abstract readMulticenter StudyObservational Study
In one paragraphObservational study in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
28 authors.
Massimo Stefano SilvettiPaediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Cardiology and Arrhythmia Unit and Syncope Unit, Bambino Gesù Children's Hospital IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Fiumicino, Rome, Italy.ORCID 0000-0001-9284-5972 Luc BruyndonckxDepartment of Paediatric Cardiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0002-2315-9925 Victor WaldmannDepartment of Paediatric Cardiology, Hôpital Necker-Enfants Malades, Université Paris Cité, Paris, France.ORCID 0000-0001-8057-1900 Roman GebauerDepartment of Paediatric Cardiology, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany.ORCID 0009-0000-9803-5532 László KörnyeiGottsegen National Cardiovascular Center, Hungarian Pediatric Heart Center, Budapest, Hungary.ORCID 0000-0001-7012-6133 Tomasz KsiazczykDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0002-6447-1261 Vieira IllikovaDepartment of Arrhythmias and Cardiac Pacing, Paediatric Cardiac Centre, National Institute of Cardiovascular Diseases, Bratislava, Slovakia.
Terezia TavacovaChildren's Heart Centre, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Joanna KwiatkowskaDepartment of Paediatric Cardiology and Congenital Heart Defects-Department of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0001-9760-1977 Vincenzo PazzanoPaediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Cardiology and Arrhythmia Unit and Syncope Unit, Bambino Gesù Children's Hospital IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Fiumicino, Rome, Italy.
Marie WilkinDepartment of Paediatric Cardiology, Hôpital Necker-Enfants Malades, Université Paris Cité, Paris, France.
Christian PaechDepartment of Paediatric Cardiology, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany.ORCID 0000-0001-9676-8994 Gábor FésüsGottsegen National Cardiovascular Center, Hungarian Pediatric Heart Center, Budapest, Hungary.ORCID 0000-0001-9328-6295 Anastasia D EgorovaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-9312-2338 Piotr WieniawskiDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0001-8711-0891 Maciej KempaDepartment of Paediatric Cardiology and Congenital Heart Defects-Department of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0002-3472-2883 Irma BattipagliaPaediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Cardiology and Arrhythmia Unit and Syncope Unit, Bambino Gesù Children's Hospital IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Fiumicino, Rome, Italy.ORCID 0000-0001-7851-8801 Sophia KlehsDepartment of Paediatric Cardiology, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany.ORCID 0000-0001-7715-2799 Michal ChalupkaDepartment of Arrhythmias and Cardiac Pacing, Paediatric Cardiac Centre, National Institute of Cardiovascular Diseases, Bratislava, Slovakia.ORCID 0000-0002-5507-8302 Reinoud E KnopsDepartment of Paediatric Cardiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0002-0772-3573 Jan JanousekChildren's Heart Centre, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.ORCID 0000-0002-4932-1150 Nico A BlomDepartment of Paediatric Cardiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0002-4823-6974 Mariolina LovecchioCardiac Rhythm Management, Boston Scientific, Milan, Italy.
Fabrizio DragoPaediatric Cardiology and Cardiac Arrhythmia/Syncope Unit, Cardiology and Arrhythmia Unit and Syncope Unit, Bambino Gesù Children's Hospital IRCCS, Via Torre di Palidoro 1, 00050 Palidoro-Fiumicino, Rome, Italy.ORCID 0000-0003-1888-373X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
aimsSubcutaneous implantable cardioverter-defibrillators (S-ICDs) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. This study aims to evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices and clinical outcomes. METHODS AND
resultsThis is an international, multicentre, observational, retrospective registry on S-ICD outcome in paediatric and young adult patients with congenital heart defects (CHD), cardiomyopathies, channelopathies, and idiopathic ventricular fibrillation (IVF). Data were collected on implantation techniques, acute and long-term outcomes, including defibrillation efficacy, inappropriate (IAS) and appropriate shocks, and complications. Follow-up data were analysed to assess device performance and safety. A total of 223 patients (mean age: 15 ± 3 years; 59% male, 53% cardiomyopathies, 18% channelopathies, 15% IVF, 14% CHD) were included. Most patients underwent implantation using an intermuscular (65%) and two-incision technique (88%). Acute defibrillation success was 100%, and no intraoperative complications occurred. The median follow-up was 28 (IQR: 12-55) months. Appropriate shocks were delivered in 41 (18%) patients (26% rate at 5 years). The first shock was effective in 92% of discrete episodes. The IAS and the complication rates were 20% and 5% at 5 years. Older age, intermuscular pocket, and two-incision technique were associated with fewer complications.
conclusionThis multicentre S-ICD European registry in paediatric and young patients demonstrated favourable outcomes, low IAS, and complication rates.
Indexed as
Death, Sudden, CardiacDefibrillators, ImplantableElectric CountershockHeart Defects, CongenitalVentricular FibrillationAdolescentAdultAge FactorsCardiomyopathiesChannelopathiesChildChild, PreschoolEuropeFemaleHumansMaleCongenital heart diseaseImplantable cardioverter-defibrillatorPaediatric ageSubcutaneous-ICDSudden cardiac death
Identifiers
PMID41166645
PMCPMC12658323
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