Evidence map›Paper›PMID 41166529›Full record

ArticleRespiration; international review of thoracic diseases2026

Endobronchial Valve Treatment Improves Regional Specific Ventilation in the Target Lung.

Sharyn A Roodenburg, Dirk-Jan Slebos, Else A M D Ter Haar, Nina Eikelis, Kristopher Nilsen, Enouschka Schleurholts, Jason P Kirkness, Tamas Ötvös, Jorine E Hartman

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In one paragraph

Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sharyn A RoodenburgDepartment of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Dirk-Jan SlebosDepartment of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Else A M D Ter HaarDepartment of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Nina Eikelis4DMedical Limited, Melbourne, Victoria, Australia.
Kristopher Nilsen4DMedical Limited, Melbourne, Victoria, Australia.
Enouschka SchleurholtsDepartment of Radiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Jason P KirknessMiller School of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami, Florida, USA.
Tamas ÖtvösMiller School of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miami, Florida, USA.
Jorine E HartmanDepartment of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, j.hartman@umcg.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Previous studies yielded inconsistent results regarding whether bronchoscopic lung volume reduction using endobronchial valves (EBVs) improves pulmonary ventilation. The aim of this study was to evaluate changes in ventilation following EBV treatment using a novel technique for assessing specific pulmonary ventilation: X-ray velocimetry (XV LVAS, 4DMedical, Los Angeles, CA, USA).

methodsPulmonary ventilation was assessed using XV pretreatment and 6 weeks after treatment. The main outcome was mean specific ventilation (MSV) (mL/mL) which is defined as the volume change in a lung region (from start to end of inspiration), divided by the volume of that region at the start of inspiration.

resultsNineteen patients were included (79% female, mean FEV

conclusionFor the first time, XV was utilized to measure specific pulmonary ventilation before and after EBV treatment. Our results demonstrate an overall increase in pulmonary ventilation across the whole lung, driven by an increase in the treated lung, despite a decrease in the non-treated lung. No association was observed between changes in pulmonary ventilation and changes in clinical outcomes. </p>.

Indexed as

BronchoscopyLungPneumonectomyPulmonary EmphysemaPulmonary VentilationAgedFemaleHumansMaleMiddle AgedCOPDEmphysemaEndobronchial valvesImagingLung volume reductionVentilation

Identifiers

PMID41166529
PMCPMC12707880

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.