ArticleProceedings of the National Academy of Sciences of the United States of America2025
LRP8 is an entry receptor for tick-borne encephalitis viruses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Article
- Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.bioRxiv : the preprint server for biology · 2026Article
- Design of a neutralizing and protective pan-encephalitic alphavirus receptor decoy protein.Science translational medicine · 2026Article
- Antiviral effect of chelerythrine chloride against tick-borne encephalitis virus.Virology journal · 2026Article
- Research progress on emerging and important Tick-Borne pathogens.Frontiers in microbiology · 2026Review
- Tick-Borne Encephalitis in the 21Le infezioni in medicina · 2026Review
- Low density lipoprotein receptor-related protein 8: a critical receptor for tick-borne encephalitis virus entry.Signal transduction and targeted therapy · 2025Article
- LRP8 is an entry receptor for tick-borne encephalitis viruses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Orthoflaviviruses are a genus of arthropod-transmitted RNA viruses that infect humans and other vertebrate animals on a global scale, resulting in extensive morbidity and mortality. Among the orthoflaviviruses, tick-borne encephalitis viruses (TBEV) are an antigenic group that causes severe neurological disease in humans. However, the entry receptors for TBEV, which contribute to cell and tissue tropism, remain largely unknown. Because recent studies identified members of the low-density lipoprotein receptor (LDLR) family as possible receptors for some orthoflaviviruses and distantly related alphaviruses, we performed a targeted screen in transgenic cells expressing different LDLR members and identified LRP8 (also called ApoER2) as a candidate receptor for TBEV strains from the five different subtypes. Genetic ablation of
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Registered trials
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