Trial reportPloS one2025
Physiology of body lateralization on regional lung ventilation and lung volumes in healthy subjects: Within-subjects design.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological Effects of Lateral Body Positioning on Regional Ventilation and Ultrasound Diaphragmatic Mobility in Healthy Subjects: an Experimental Study
Analysis of Respiratory Drive Activation, Ventilation, and Pulmonary Aeration Resulting From Body Lateralization in Critically Ill Patients Under Mechanical Ventilation
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLateral positioning improves pulmonary mechanics and lung volumes, but its effects in healthy adults remain unclear due to individual variability.
objectiveTo analyze the acute effects of lateral body positioning on regional lung ventilation and lung volumes in healthy adults.
methodsThis within-subject study included two protocols: supine and left-lateral position (unilateral) with repeated measures and supine, left, and right-lateral positions (bilateral). All positions were performed at 30° for 5 minutes on an automated rotation bed. Electrical Impedance Tomography measured regional lung ventilation (%) and end-expiratory lung volumes (EELV) across four lung regions: (anterior right [AR] and left [AL]; posterior right [PR], and left [PL]). Linear mixed models assessed the influence of body position and individual variability on regional ventilation and lung volumes, while the Restricted Maximum Likelihood method compared between right- and left-lateral positioning.
resultsIn the unilateral protocol (n = 29; 58.6% male; 22.8 ± 4.0 years), left-lateral positioning decreased regional ventilation in nondependent regions (AR: -0.96%, PR: -1.63%) and increased it in dependent regions (PL: 1.17%, AL: 1.42%) versus supine (p < 0.001). EELV increased in PL (+ 0.7 mL/kg PBW), PR (+2.0), and AR (+2.8), but decreased in AL (-2.3) (p < 0.001). In the bilateral protocol (n = 10, 70% male; 23.6 ± 3.2 years), regional ventilation showed no significant effects of position, ROI, or interaction (p > 0.05). However, EELV varied significantly with body position (p < 0.001), with no isolated ROI effect (p = 1.000).
conclusionsLateral positioning improves regional ventilation in dependent lung regions and increases EELV in nondependent and posterior dependent lung regions, regardless of side.
trial registrationClinicalTrials.gov [NCT06044896].
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.