Dosage-dependent regulation of embryonic diapause by sorbitol dehydrogenase in the silkworm, Bombyx mori.

Dongbin Chen, Dehong Yang, Xin Fu, Haixu Bian, Yongping Huang, Yanqun Liu, Zulian Liu

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Article in PLoS genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Dongbin ChenSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0009-0003-8396-1025

Dehong YangSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.

Xin FuDepartment of Sericulture, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, China.

Haixu BianDepartment of Sericulture, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, China.

Yongping HuangSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-3266-1327

Yanqun LiuDepartment of Sericulture, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, China.ORCID https://orcid.org/0000-0001-9025-1986

Zulian LiuSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-7942-8322

Funding

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6 · The paper itself

Abstract

Insects have evolved diapause to cope with harsh environmental conditions, during which their metabolism undergoes significant remodeling. The silkworm, Bombyx mori, enters diapause in the early embryonic stage, a process critically regulated by the sorbitol metabolism pathway and its key enzyme, sorbitol dehydrogenase (SDH). Nevertheless, the precise involvement of SDH in the diapause regulation of the silkworm remains to be fully understood. In this study, we identified that BmSdh2 is highly expressed in diapause-destined silkworm embryos through RNA-seq analysis. Genetic manipulation of BmSdh2 expression significantly influenced diapause progression: complete homozygous knockout of BmSdh2 led to diapause termination, whereas partial loss-of-function mutations maintained the wild-type diapause phenotype. Furthermore, integrative LC-MS/MS, metabolomic, and lipidomic analyses demonstrated that BmSdh2 dosage critically modulates diapause maintenance. These findings highlight BmSdh2 as a novel and potentially central molecular regulator in the silkworm diapause pathway.

Indexed as

BombyxDiapauseDiapause, InsectInsect ProteinsL-Iditol 2-DehydrogenaseAnimalsEmbryo, NonmammalianGene DosageGene Expression Regulation, DevelopmentalInsect ProteinsL-Iditol 2-Dehydrogenase

Identifiers

PMID41166362

DOI10.1371/journal.pgen.1011933

PMCPMC12594423

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