Observational studyPloS one2025
Gestational age, birth weight, and infant 1-year mortality risk: A large-scale analysis of 6.9 million births from the Japanese National registry.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Scientific Perspectives on Evaluating Fetal Physical Development Around Birth: Historical Approaches and Practices in Japan.The journal of obstetrics and gynaecology research · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJapan's low infant mortality rates (IMR) reflect advancements in neonatal care. However, a comprehensive understanding of factors influencing long-term infant mortality nationwide is lacking. We examined the 1-year relationships between gestational age (GA), birth weight, small-for-gestational-age (SGA) status, and infant mortality risk.
objectiveThis study aimed to estimate the 1-year survival probability of infants stratified by GA, birth weight and SGA status.
methodsThis study is an observational study using Japan's vital registration data between 2012 and 2018. Whole national birth and death registration data was analyzed. 6,918,305 births and 12,440 deaths within the first year of age were included. The main outcome is 1-year infant mortality and survival curve.
resultsInfants born preterm, and SGA exhibited elevated mortality rates (15 and 8.5 per 1,000, respectively). Survival probability varied significantly based on GA, birth weight, and SGA status. Overall 1-year mortality risk was 1.8 per 1,000 live births with survival probabilities notably increasing with GA. Late preterm and early term births also exhibited increased mortality risks compared to full term infants (e.g., 2.2 per 1,000 live births if born at 37 weeks vs 0.76 at 39 weeks). Notably, late preterm births constituted the majority of preterm births and were associated with major mortality risks.
conclusionsThis study, extending beyond previous short-term research, provides insights into long-term infant mortality risks in Japan, underscoring the importance of gestational age, birth weight, and SGA status in infant mortality risk among live births. Further study to elucidate the reasons behind pregnancy termination decisions and the specifics of antenatal and neonatal care is needed to better understand the factors influencing infant mortality.
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