ArticlePloS one2025
Epigenetic regulation of inflammation in post-operative organ dysfunction: A scoping review protocol.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Human lncRNA, hLinfRNA7 (IDO1-AS) Regulates Cytokine Expression, Tryptophan Catabolism, and Inflammatory Response in Macrophage.Molecular and cellular biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe inflammatory response to surgery is complex, dynamic and exhibits variability in magnitude and duration among patients undergoing similar operations. Dysregulated inflammation is associated with post-operative complications such as organ dysfunction, particularly after major surgery. Epigenetic modifications enhance (or suppress) selective gene transcription without altering DNA sequences, effectively regulating gene expression. Several studies have investigated epigenetic regulation of the immune system in the context of surgery, often studying organ-specific dysfunction.
objectivesWe propose a novel scoping review protocol to collate and synthesise existing studies investigating epigenetic regulation of post-operative inflammation, as a key mechanism of post-operative organ dysfunction and complications. We will map knowledge gaps to inform future research in this emerging field. METHODS AND ANALYSIS: This scoping review protocol has been created following the Joanna Brigg's Institute (JBI) updated guidelines for conducting scoping reviews. The protocol has been further examined alongside the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews (PRISMA-ScR) checklist and is registered on Open Science Framework (doi.org/10.17605/OSF.IO/CE8FB). Published human studies from 1946 to the present will be considered. Studies will include patients undergoing surgery, where epigenetic regulation of the immune system is investigated alongside assessment of organ dysfunction or complications. Searches will be conducted using Medline (via OVID) and Embase. Two reviewers will independently screen titles, abstracts and full texts of studies meeting the inclusion criteria. Following study screening, a customised data extraction form will collect study information related to the review questions and inclusion criteria (population, concept, context). Results will be presented by diagrammatic mapping of studies and tabular representation of findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.