Evidence map›Paper›PMID 41166261›Full record

ReviewChemical reviews2025

Catalytic Enantioselective Methods for Synthesis of 1,2-Amino Tertiary Alcohols and Their Analogues.

Steven J Malcolmson, Faraan Rahim

Abstract readReview
In one paragraph

Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven J MalcolmsonDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID 0000-0003-3229-0949
Faraan RahimDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Funding

Strategies for the Catalytic Synthesis of Nitrogen-Containing MoleculesR35GM145285 · NIGMS · DUKE UNIVERSITY · PI Steven Joseph Malcolmson · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM145285
6 · The paper itself

Abstract

Vicinal amino alcohols, also called 1,2- or β-amino alcohols, are an important class of chemical modalities that may serve as chiral ligands for metal-based catalysts or as catalysts themselves and are found within numerous pharmaceutically active compounds. As such, a multitude of strategies have been adopted for their preparation, with traditional approaches leveraging diastereoselective synthesis of this scaffold based upon existing stereochemistry within a substrate. Many times, naturally occurring chiral variants or syntheses of the moiety from chiral natural sources have been utilized. Given their prominence, there have been myriad strategies developed for the catalytic enantioselective synthesis of β-amino alcohols; however, these have largely focused on the formation of

Identifiers

PMID41166261
PMCPMC12616711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.