Evidence map›Paper›PMID 41166228›Full record

ArticleTechnology in cancer research & treatment

VMAT with CCC Algorithm Optimizes Trismus Prevention: Dose-Response Analysis of Jaw Muscles Dmean and Dmax in T3-T4 Nasopharyngeal Carcinoma.

RunFan Chen, Jun Chen, Xuanyu Liu, Linlong Shao, Jiang Zeng, Yi Guo, Linzhen Lan, Feibao Guo

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Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

RunFan ChenDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0003-0282-3708
Jun ChenDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Xuanyu LiuDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Linlong ShaoDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Jiang ZengDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yi GuoDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Linzhen LanDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Feibao GuoDepartment of Radiotherapy, Cancer Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0003-2754-8212

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionDespite technological advances in radiotherapy, trismus persists as a treatment-limiting toxicity in T3-T4 nasopharyngeal carcinoma (NPC) survivors, with current guidelines lacking evidence-based dose constraints for masticatory muscle sparing. This study aimed to establish dose-response relationships and propose clinically actionable thresholds for trismus prevention using volumetric modulated arc therapy (VMAT) with collapsed cone convolution (CCC) dose calculation.MethodsIn this retrospective cohort study, 60 T3-T4 NPC patients treated with VMAT (CCC algorithm) were stratified by trismus severity. Dosimetric parameters (Dmean/Dmax) of jaw-opening (digastric, mylohyoid, geniohyoid) and closing muscles (masseter, pterygoids) were analyzed. Univariate (t-tests) and multivariable logistic regression identified predictors; ROC curves determined optimal dose constraints.ResultsUnivariate analysis: digastric Dmean showed the strongest association with trismus (p = .0049), followed by mylohyoid Dmean (p = .088) and masseter Dmean (p = .063). Multivariable analysis: digastric Dmean retained marginal significance (β=-1.58 × 10

Indexed as

AlgorithmsMasticatory MusclesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRadiation InjuriesRadiotherapy, Intensity-ModulatedTrismusAdultAgedDose-Response Relationship, RadiationFemaleHumansMaleMiddle AgedNeoplasm StagingOrgans at Riskdose constraintsnasopharyngeal carcinomatrismusvolumetric modulated arc therapy

Identifiers

PMID41166228
PMCPMC12576174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.