Evidence map›Paper›PMID 41166166›Full record

ArticleShock (Augusta, Ga.)2026

Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty.

Charles C Caldwell, Robert Maile, Monty B Mazer, Patrick W McGonagill, Christian B Bergmann, Robert W Gould, Mahil Rao, Miguel Hernández-Ríos, Ricardo F Ungaro, Tyler J Loftus and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Charles C CaldwellDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Robert MaileDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Monty B MazerDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Patrick W McGonagillDepartment of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Christian B BergmannDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Robert W GouldDepartment of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota.
Mahil RaoDepartment of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Miguel Hernández-RíosDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Ricardo F UngaroDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Tyler J LoftusDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Philip A EfronDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Kenneth E RemyDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Scott C BrakenridgeDepartment of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington.
Vladimir P BadovinacInterdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Thomas S GriffithDepartment of Urology, University of Minnesota Medical School, Minneapolis, Minnesota.
Richard S HotchkissDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Lyle L MoldawerDepartment of Surgery, Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.

Funding

Renewal: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis PathobiologyRM1GM139690 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron, Michael Paul Kladde · 2021 to 2026
$10.3M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Enhancing Innate and Adaptive Immunity to Improve Sepsis SurvivalR35GM126928 · NIGMS · WASHINGTON UNIVERSITY · PI Richard Samuel Hotchkiss · 2018 to 2026
$4.7M
Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)R01GM139046 · NIGMS · UNIVERSITY OF FLORIDA · PI MAILE, ROBERT · 2020 to 2024
$4.2M
CD4 T cell dysregulation and reprogramming in sepsisR35GM140881 · NIGMS · UNIVERSITY OF MINNESOTA · PI Thomas S Griffith · 2021 to 2026
$2.4M
R35 Equipment SupplementR35GM140806 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2021 to 2025
$2.2M
Immunological Endotyping of Chronic Critical Illness after Severe Trauma or Sepsis: Administrative SupplementR35GM142481 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRAKENRIDGE, SCOTT CHARLES · 2021 to 2025
$2.0M
Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses stateR35GM134880 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2020 to 2024
$1.9M
Aligning Patient Acuity with Resource Intensity after Major SurgeryR01GM149657 · NIGMS · UNIVERSITY OF FLORIDA · PI Tyler J Loftus · 2023 to 2026
$1.3M
BLRD VA IK6 BX006192NIGMS NIH HHS R01 GM139046NIGMS NIH HHS R01 GM149657NIGMS NIH HHS R35 GM126928NIGMS NIH HHS R35 GM134880NIGMS NIH HHS R35 GM140806NIGMS NIH HHS R35 GM140881NIGMS NIH HHS R35 GM142481NIGMS NIH HHS RM1 GM139690NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41166166
PMCPMC13584922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.